ArticleJournal of the American Society of Nephrology : JASN2008
Renin-angiotensin system blockade is renoprotective in immune complex-mediated glomerulonephritis.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Real-world assessment of sparsentan's drug safety framework.Renal failure · 2025Article
- Sparsentan is superior to losartan in the gddY mouse model of IgA nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype.American journal of physiology. Renal physiology · 2024Article
- Flexible and multifaceted: the plasticity of renin-expressing cells.Pflugers Archiv : European journal of physiology · 2022Review
- Metformin ameliorates the severity of experimental Alport syndrome.Scientific reports · 2021Article
- Functional Metabolomics Analysis Elucidating the Metabolic Biomarker and Key Pathway Change Associated With the Chronic Glomerulonephritis and Revealing Action Mechanism of Rhein.Frontiers in pharmacology · 2020Article
- Lineage tracing aged mouse kidneys shows lower number of cells of renin lineage and reduced responsiveness to RAAS inhibition.American journal of physiology. Renal physiology · 2018Article
- Immunologic Effects of the Renin-Angiotensin System.Journal of the American Society of Nephrology : JASN · 2017Review
- Renin-Angiotensin-Aldosterone System Inhibition Increases Podocyte Derivation from Cells of Renin Lineage.Journal of the American Society of Nephrology : JASN · 2016Article
- ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2015Article
- Glomerular cell death and inflammation with high-protein diet and diabetes.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013Article
- Reversibility of structural and functional damage in a model of advanced diabetic nephropathy.Journal of the American Society of Nephrology : JASN · 2013Article
- Podocyte dysfunction in aging--related glomerulosclerosis.Frontiers in bioscience (Scholar edition) · 2011Review
- Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction.BMC research notes · 2010Article
- BTBR Ob/Ob mutant mice model progressive diabetic nephropathy.Journal of the American Society of Nephrology : JASN · 2010Article
- Sexual dimorphism in the blood pressure response to angiotensin II in mice after angiotensin-converting enzyme blockade.American journal of hypertension · 2010Article
- Renovascular and renoprotective properties of telmisartan: clinical utility.International journal of nephrology and renovascular disease · 2010Article
- Deletion of activating Fcgamma receptors does not confer protection in murine cryoglobulinemia-associated membranoproliferative glomerulonephritis.The American journal of pathology · 2009Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Blockade of the renin-angiotensin system is renoprotective in a variety of chronic nephropathies, but the direct effect of such treatment in active, immune complex-mediated glomerulonephritis is unknown. This study investigated the short- and long-term effects of an angiotensin-converting enzyme inhibitor (enalapril) and an angiotensin II type 1 receptor blocker (losartan) in thymic stromal lymphopoietin transgenic (TSLPtg) mice, which develop mixed cryoglobulinemia and severe cryoglobulinemia-associated membranoproliferative glomerulonephritis. Enalapril and losartan each reduced hypertension, proteinuria, glomerular extracellular matrix deposition, and mesangial cell activation in TSLPtg mice. These renoprotective effects were not observed with hydralazine treatment, despite a similar antihypertensive effect. Treatment with enalapril or losartan also decreased renal plasminogen activator inhibitor-1 in TSLPtg mice, assessed by immunohistochemistry and quantitative real-time reverse transcriptase-PCR. None of the treatments affected immune complex deposition or macrophage infiltration. Overall, enalapril- and losartan-treated TSLPtg mice survived significantly longer than untreated TSLPtg mice. These studies demonstrate that angiotensin blockade may provide renoprotective benefits, independent of its BP-lowering effect, in the treatment of active immune complex-mediated glomerulonephritis.
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