ArticleJournal of the American Society of Nephrology : JASN2008
Role of integrins in the assembly and function of hensin in intercalated cells.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Cancer cell extravasation requiresBritish journal of cancer · 2024Observational
- GDF15, an Emerging Player in Renal Physiology and Pathophysiology.International journal of molecular sciences · 2024Review
- The laminin-binding integrins regulate nuclear factor κB-dependent epithelial cell polarity and inflammation.Journal of cell science · 2021Article
- Renal acid-base regulation: new insights from animal models.Pflugers Archiv : European journal of physiology · 2015Review
- Integrated compensatory network is activated in the absence of NCC phosphorylation.The Journal of clinical investigation · 2015Article
- First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct.Histochemistry and cell biology · 2014Article
- Integrins and cAMP mediate netrin-induced growth cone collapse.Brain research · 2013Article
- Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate-recognition domain.American journal of physiology. Renal physiology · 2013Article
- Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Regulated acid-base transport in the collecting duct.Pflugers Archiv : European journal of physiology · 2009Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Epithelial differentiation proceeds in at least two steps: Conversion of a nonepithelial cell into an epithelial sheet followed by terminal differentiation into the mature epithelial phenotype. It was recently discovered that the extracellular matrix (ECM) protein hensin is able to convert a renal intercalated cell line from a flat, squamous shape into a cuboidal or columnar epithelium. Global knockout of hensin in mice results in embryonic lethality at the time that the first columnar cells appear. Here, antibodies that either activate or block integrin beta1 were used to demonstrate that activation of integrin alpha v beta 1 causes deposition of hensin in the ECM. Once hensin polymerizes and deposits into the ECM, it binds to integrin alpha 6 and mediates the conversion of epithelial cells to a cuboidal phenotype capable of apical endocytosis; therefore, multiple integrins play a role in the terminal differentiation of the intercalated cell: alpha v beta 1 generates polymerized hensin, and another set of integrins (containing alpha 6) mediates signals between hensin and the interior of the cells.
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