ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Electrophysiological and behavioral evidence demonstrating that predator detection alters adaptive behaviors in the snail Lymnaea.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Not too different: Wild Lymnaea learning at the pondside and in the lab.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- First evidence of an anxiety-like behavior and its pharmacological modulation in a molluscan model organism, Lymnaea stagnalis.Translational psychiatry · 2025Article
- An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms of anti-predator behavior in the great ramshorn snail (Planorbarius corneus).PloS one · 2024Article
- Fluoride alters feeding and memory in Lymnaea stagnalis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- A flavonoid, quercetin, is capable of enhancing long-term memory formation if encountered at different times in the learning, memory formation, and memory recall continuum.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- Green tea and cocoa enhance cognition inCommunicative & integrative biology · 2018Article
- Impairing DNA methylation obstructs memory enhancement for at least 24 hours inCommunicative & integrative biology · 2017Article
- Training Lymnaea in the presence of a predator scent results in a long-lasting ability to form enhanced long-term memory.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Combining stressors that individually impede long-term memory blocks all memory processes.PloS one · 2013Article
- How stress alters memory in 'smart' snails.PloS one · 2012Article
- Interaction between environmental stressors mediated via the same sensory pathway.Communicative & integrative biology · 2011Article
- The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea.Molecular brain · 2010Article
- A clash of stressors and LTM formation.Communicative & integrative biology · 2008Article
- Epicatechin, a component of dark chocolate, enhances memory formation if applied during the memory consolidation period.Communicative & integrative biologyArticle
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2 authors.
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Abstract
Stress has been shown to both impair and enhance learning, long-term memory (LTM) formation, and/or its recall. The pond snail, Lymnaea stagnalis, both detects and responds to the scent of a crayfish predator with multiple stress-related behavioral responses. Using both behavioral and electrophysiological evidence, this investigation is a first attempt to characterize how an environmentally relevant stressor (scent of a predator) enhances LTM formation in Lymnaea. Using a training procedure that, in "standard" pond water (PW), results in an intermediate-term memory that persists for only 3 h, we found that training snails in "crayfish effluent" (CE) induces a memory that persists for 48 h (i.e., its now an LTM). In addition, if we use a training procedure that in PW produces an LTM that persists for 1 d, we find that snails trained in CE have an LTM that persists for at least 8 d. Furthermore, we describe how a single neuron (RPeD1), which has been shown to be a necessary site for LTM formation, reflects the behavioral changes in its firing properties that persist for the duration of the LTM. Finally, Lymnaea exhibit context-specific memory, that is, when a memory is formed in a specific context (food odorant), it is only recalled in that context. Here, we found that snails trained in CE demonstrate context generalization, that is, memory is recalled in multiple contexts. All data are consistent with the hypothesis that learning in a stressful, yet biologically relevant, environment enhances LTM and prolongs its retention.
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