ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure.The Journal of physiology · 2020Article
- Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation.Frontiers in immunology · 2020Review
- Inflammation, Cancer and Immunity-Implication of TRPV1 Channel.Frontiers in oncology · 2019Review
- Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation.Frontiers in physiology · 2017Article
- Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
- Role of TRP channels in the cardiovascular system.American journal of physiology. Heart and circulatory physiology · 2015Review
- TRPV1 antagonism by capsazepine modulates innate immune response in mice infected with Plasmodium berghei ANKA.Mediators of inflammation · 2014Article
- TRPV1 ablation aggravates inflammatory responses and organ damage during endotoxic shock.Clinical and vaccine immunology : CVI · 2013Article
- Role of the transient receptor potential vanilloid type 1 channel in renal inflammation induced by lipopolysaccharide in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Aging reverses the role of the transient receptor potential vanilloid-1 channel in systemic inflammation from anti-inflammatory to proinflammatory.Cell cycle (Georgetown, Tex.) · 2012Article
- Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord.Acta pharmacologica Sinica · 2011Article
- Disruption of the transient receptor potential vanilloid 1 can affect survival, bacterial clearance, and cytokine gene expression during murine sepsis.Anesthesiology · 2011Article
- Role of the transient receptor potential vanilloid 1 in inflammation and sepsis.Journal of inflammation research · 2011Article
- Inflammation compromises renal dopamine D1 receptor function in rats.American journal of physiology. Renal physiology · 2009Article
- The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.Pharmacological reviews · 2009Review
- Transient receptor potential vanilloid channels in hypertension, inflammation, and end organ damage: an imminent target of therapy for cardiovascular disease?Current opinion in cardiology · 2008Review
- Central mediators involved in the febrile response: effects of antipyretic drugs.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This study was designed to test the hypothesis that the transient receptor potential vanilloid type 1 (TRPV1) channel, expressed primarily in sensory nerves, and substance P (SP), released by sensory nerves, play a protective role against lipopolysaccharide (LPS)-induced hypotension. LPS (10 mg/kg iv) elicited tachycardia and hypotension in anesthetized male Wistar rats, which peaked at 10 min and gradually recovered 1 h after the injection. Blockade of TRPV1 with its selective antagonist capsazepine (CAPZ, 3 mg/kg iv) impaired recovery given that the fall in mean arterial pressure (MAP) was greater 1 h after CAPZ plus LPS injections compared with LPS injection alone (45 +/- 5 vs. 25 +/- 4 mmHg, P < 0.05). Blockade of the neurokinin 1 (NK1) receptor with its selective antagonists RP-67580 (5 mg/kg iv) or L-733,060 (4 mg/kg iv) prevented recovery, considering that falls in MAP were not different 1 h after injections of NK1 antagonists plus LPS from their peak decreases (66 +/- 9 vs. 74 +/- 5 mmHg or 60 +/- 7 vs. 69 +/- 3 mmHg, respectively, P > 0.05). LPS increased plasma SP, norepinephrine (NE), and epinephrine (Epi) levels compared with vehicles, and the increases in plasma SP, NE, and Epi were significantly inhibited by CAPZ or RP-67580. The survival rate at 24 or 48 h after LPS injection (20 mg/kg ip) was lower in conscious rats pretreated with CAPZ or RP-67580 compared with rats treated with LPS alone (P < 0.05). Thus our results show that the TRPV1, possibly via triggering release of SP which activates the NK1 and stimulates the sympathetic axis, plays a protective role against endotoxin-induced hypotension and mortality, suggesting that TRPV1 receptors are essential in protecting vital organ perfusion and survival during the endotoxic condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.