Trial reportBrain : a journal of neurology2008
Short-term variations in response distribution to cortical stimulation.
Trial report in Brain : a journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Electrical stimulation for the induction of seizures is safe, well-tolerated and high-yield in children with drug-resistant epilepsy.Epilepsy & behavior : E&B · 2026Article
- The Physics and Physiology of Electrical Stimulation of the Brain.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- Can electrical stimulation replace spontaneous seizures in epilepsy surgery?medRxiv : the preprint server for health sciences · 2025Article
- Intraoperative somatosensory evoked potential (SEP) monitoring: an updated position statement by the American Society of Neurophysiological Monitoring.Journal of clinical monitoring and computing · 2024Review
- Pan-cortical electrophysiologic changes underlying attention.Scientific reports · 2024Article
- Neural mass modeling of slow-fast dynamics of seizure initiation and abortion.PLoS computational biology · 2020Article
- Band power modulation through intracranial EEG stimulation and its cross-session consistency.Journal of neural engineering · 2020Article
- Attention, Not Performance, Correlates With Afterdischarge Termination During Cortical Stimulation.Frontiers in human neuroscience · 2020Article
- Applying a Sensing-Enabled System for Ensuring Safe Anterior Cingulate Deep Brain Stimulation for Pain.Brain sciences · 2019Article
- Mesoscopic neuron population modeling of normal/epileptic brain dynamics.Cognitive neurodynamics · 2018Article
- Understanding Epileptiform After-Discharges as Rhythmic Oscillatory Transients.Frontiers in computational neuroscience · 2017Article
- Neurophysiological features of Internet gaming disorder and alcohol use disorder: a resting-state EEG study.Translational psychiatry · 2015Article
- Proceedings of the Fifth International Workshop on Advances in Electrocorticography.Epilepsy & behavior : E&B · 2014Review
- Dynamic mechanisms underlying afterdischarge: a human subdural recording study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2014Article
- Frequency and time-frequency analysis of intraoperative ECoG during awake brain stimulation.Frontiers in neuroengineering · 2013Article
- Subdural electrodes.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010Review
- Toward rational design of electrical stimulation strategies for epilepsy control.Epilepsy & behavior : E&B · 2010Review
- When is electrical cortical stimulation more likely to produce afterdischarges?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2010Article
- Studying network mechanisms using intracranial stimulation in epileptic patients.Frontiers in systems neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Patterns of responses in the cerebral cortex can vary, and are influenced by pre-existing cortical function, but it is not known how rapidly these variations can occur in humans. We investigated how rapidly response patterns to electrical stimulation can vary in intact human brain. We also investigated whether the type of functional change occurring at a given location with stimulation would help predict the distribution of responses elsewhere over the cortex to stimulation at that given location. We did this by studying cortical afterdischarges following electrical stimulation of the cortex in awake humans undergoing evaluations for brain surgery. Response occurrence and location could change within seconds, both nearby to and distant from stimulation sites. Responses might occur at a given location during one trial but not the next. They could occur at electrodes adjacent or not adjacent to those directly stimulated or to other electrodes showing afterdischarges. The likelihood of an afterdischarge at an individual site after stimulation was predicted by spontaneous electroencephalographic activity at that specific site just prior to stimulation, but not by overall cortical activity. When stimulation at a site interrupted motor, sensory or language function, afterdischarges were more likely to occur at other sites where stimulation interrupted similar functions. These results show that widespread dynamic changes in cortical responses can occur in intact cortex within short periods of time, and that the distribution of these responses depends on local brain states and functional brain architecture at the time of stimulation. Similar rapid variations may occur during normal intracortical communication and may underlie changes in the cortical organization of function. Possibly these variations, and the occurrence and distribution of responses to cortical stimulation, could be predicted. If so, interventions such as stimulation might be used to alter spread of epileptogenic activity, accelerate learning or enhance cortical reorganization after brain injury.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.