Evidence map›Paper›PMID 1833724›Full record

ArticleNucleic acids research1991

Evolutionary conservation of the spliceosomal protein, U2B''.

G G Simpson, P Vaux, G Clark, R Waugh, J D Beggs, J W Brown

Open access · greenAbstract read
In one paragraph

Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Functional redundancy of worm spliceosomal proteins U1A and U2B''.Proceedings of the National Academy of Sciences of the United States of America · 2007
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  9. Review
  10. Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors.Proceedings of the National Academy of Sciences of the United States of America · 1996
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

G G SimpsonDepartment of Cellular and Molecular Genetics, Scottish Crop Research Institute, Invergowrie, Dundee, UK.
P Vaux
G Clark
R Waugh
J D Beggs
J W Brown
Crop Research Institute · CZUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

U1 and U2snRNPs play key roles in pre-mRNA splicing. The interactions between the U1 and U2snRNP-specific proteins, U1A, U2A' and U2B'' and their respective UsnRNAs are of interest both to elucidate their roles in splicing, and as models to study RNA-protein interactions. We have cloned a full-length cDNA, encoding U2B'', from potato. This is the first report of a sequence for a plant UsnRNP protein. The plant U2B'' sequence exhibits extensive similarity with the human U2B'' protein at both the DNA and amino acid levels. The evolutionary conservation at the protein level, particularly in sequences implicated in determining specific binding to U2snRNA, suggests conservation of U2B'' function from plants to man. The significance of amino acid substitutions in the RNP-80 motif with respect to U2snRNA binding in plants is discussed.

Indexed as

Amino Acid SequenceBase SequenceCloning, MolecularHumansImmunoblottingMolecular Sequence DataPlant ProteinsPrecipitin TestsProtein ConformationRibonucleasesRibonucleoproteinsRibonucleoproteins, Small NuclearSequence AlignmentSolanum tuberosumPlant ProteinsRibonucleasesRibonucleoproteinsRibonucleoproteins, Small Nuclear

Identifiers

PMID1833724
PMCPMC328878
OpenAlexW2066811418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.