ArticleClinical and experimental immunology2008
Involvement of innate immunity in the pathogenesis of intestinal Behçet's disease.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Curcumin in Behçet's disease: exploring therapeutic potential, evidence, and key research gaps.Inflammopharmacology · 2026Review
- Behçet-like Syndromes: A Comprehensive Review.Dermatopathology (Basel, Switzerland) · 2026Review
- Heat Shock Proteins in Behçet SyndromeBalkan medical journal · 2023Review
- The role of miRNAs in Behçet's disease.Frontiers in immunology · 2023Review
- Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Behçet's disease.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Repeated Necrotizing Lymphadenitis with MEFV Gene Mutations.Internal medicine (Tokyo, Japan) · 2022Article
- Behcet's Disease: An In-Depth Review about Pathogenesis, Gastrointestinal Manifestations, and Management.Inflammatory intestinal diseases · 2021Review
- Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet's Disease.Frontiers in cell and developmental biology · 2021Review
- HSV-Induced Systemic Inflammation as an Animal Model for Behçet's Disease and Therapeutic Applications.Viruses · 2018Review
- Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study.Cancer medicine · 2018Article
- Influence of corticosteroid therapy on IL-18 and nitric oxide production during Behçet's disease.Inflammopharmacology · 2018Article
- Analysis of Th Cell-related Cytokine Production in Behçet Disease Patients with Uveitis Before and After Infliximab Treatment.Ocular immunology and inflammation · 2017Article
- Cytokine Signatures in Mucocutaneous and Ocular Behçet's Disease.Frontiers in immunology · 2017Article
- Bifidobacteria Abundance-Featured Gut Microbiota Compositional Change in Patients with Behcet's Disease.PloS one · 2016Article
- Putative Role of Serum Amyloid-A and Proinflammatory Cytokines as Biomarkers for Behcet's Disease.Medicine · 2015Observational
- Behçet's disease-like syndrome secondary to microbial infection: a case report and review of the literature.International journal of clinical and experimental pathology · 2015Review
- Diagnosis and management of intestinal Behçet's disease.Clinical journal of gastroenterology · 2014Review
- Innate and Adaptive Responses to Heat Shock Proteins in Behcet's Disease.Genetics research international · 2013Review
- Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease.Genetics research international · 2013Review
- NOD2 is highly expressed in Behçet disease with pulmonary manifestations.Journal of inflammation (London, England) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of excessive T helper 1 (Th1) cell functions in the pathogenesis of Behçet's disease (BD) has been reported. We therefore studied Toll-like receptor (TLR)-expressing cells, which play important roles in innate immunity in patients with BD. Peripheral blood mononuclear cells (PBMC) of BD and healthy controls, and tissue specimens of intestinal BD and Crohn's disease (CD) were analysed for messenger RNA (mRNA) and protein expressions by reverse transcription-polymerase chain reaction and immunostaining respectively. PBMC of BD expressed TLR-2 and TLR-4 mRNA almost comparable with healthy controls. Intestinal lesions of BD expressed TLR-2 and TLR-4 mRNA consistently. In contrast, TLR-4 mRNA was expressed preferentially and TLR-2 mRNA was expressed less frequently in CD lesions. In intestinal samples of BD, TLR-2 and TLR-4 mRNA were detected in ileocaecal ulcer lesions, but not in unaffected sites of the same sample, indicating the association of the TLR expression with the disease manifestation of intestinal BD. TLR-2-expressing cells which were simultaneously cluster of distribution (CD)68-positive produced interleukin (IL)-12 in the lesions, indicating the participation of TLR-2-expressing cells in the Th1 skewed responses in vivo. As a possible ligand of TLR-2, in BD self-heat shock protein 60 was expressed in peripheral blood lymphocytes and intestinal tissues. Collectively, TLR-2-expressing cells as well as TLR-4-expressing cells accumulated in the intestinal lesions of BD. IL-12 produced by TLR-2-expressing cells may contribute to the induction of Th1-dominant immune responses in intestinal BD.
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Registered trials
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