ArticleMolecular and cellular biology1991
Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment.Frontiers in immunology · 2022Article
- Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Transcription · 2015Review
- Article
- Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors.Journal of cellular biochemistry · 2009Article
- Tandemization of a subregion of the enhancer sequences from SRS 19-6 murine leukemia virus associated with T-lymphoid but not other leukemias.Journal of virology · 1999Article
- Positive and negative regulation of V(D)J recombination by the E2A proteins.The Journal of experimental medicine · 1999Article
- Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo.Molecular and cellular biology · 1998Article
- The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Molecular and cellular biology · 1998Article
- An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.The Journal of experimental medicine · 1997Article
- Identification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer.Molecular and cellular biology · 1995Article
- The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.Molecular and cellular biology · 1995Article
- Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains.Molecular and cellular biology · 1994Article
- Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.The Journal of experimental medicine · 1994Article
- Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor.Molecular and cellular biology · 1994Article
- Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.Molecular and cellular biology · 1994Article
- Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.Molecular and cellular biology · 1993Article
- Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.Molecular and cellular biology · 1993Article
- PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
A T-cell-specific transcriptional enhancer was previously identified within the J delta 3-C delta intron of the human T-cell receptor (TCR) delta gene, and seven distinct binding sites for nuclear factors (delta E1 to delta E7) were defined by DNase I footprinting. In this study, we conducted a detailed functional analysis of the various cis-acting DNA sequence elements of the enhancer and show that a 60-bp fragment encompassing delta E3 and delta E4 displays potent enhancer activity, as judged by its ability to activate transcription from the V delta 1 promoter. We show that the interaction of nuclear factors with the delta E3 site is essential for enhancer activity. This element displays significant activity in the absence of additional segments of the enhancer. Further, methylation interference and in vitro mutagenesis identify a site within delta E3 that mediates the binding of two nuclear factors (NF-delta E3A and NF-delta E3C) and that is required for significant transcriptional activation by the enhancer. NF-delta E3C is ubiquitous and may be identical to a previously characterized microE3-binding factor. NF-delta E3A is preferentially expressed in T lymphocytes, and we suggest that this factor may play the dominant role in transcriptional activation through the delta E3 site. This factor interacts with the sequence TGTGGTTT, a motif that is also found within the enhancers of additional TCR and CD3 genes. Nuclear factor binding to delta E4 is also analyzed. One of three specific complexes formed with a delta E4 probe appears to be T-cell specific.
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