Evidence map›Paper›PMID 18335973›Full record

ReviewChemical reviews2008

Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.

Vijay M Krishnamurthy, George K Kaufman, Adam R Urbach, Irina Gitlin, Katherine L Gudiksen, Douglas B Weibel, George M Whitesides

Abstract readReview
In one paragraph

Review in Chemical reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 213 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Introduction to Carbonic Anhydrase.Sub-cellular biochemistry · 2026
    Review
  16. Article
  17. Di-Journal of medicinal chemistry · 2025
    Article
  18. Article
  19. Article
  20. Article

153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vijay M KrishnamurthyDepartment of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
George K Kaufman
Adam R Urbach
Irina Gitlin
Katherine L Gudiksen
Douglas B Weibel
George M Whitesides

Funding

Multivalency: Mechanisms and ApplicationsR01GM030367 · NIGMS · HARVARD UNIVERSITY · PI WHITESIDES, GEORGE M · 1985 to 2010
$3.0M
Capillary Electrophoresis and Protein BiophysicsR01GM051559 · NIGMS · HARVARD UNIVERSITY · PI WHITESIDES, GEORGE M · 1994 to 2010
$2.6M
ENZYMES AS CATALYSTS IN THE SYNTHESIS OF CARBOHYDRATESR37GM030367 · NIGMS · HARVARD UNIVERSITY · PI WHITESIDES, GEORGE M · 1991 to 2000
$572k
Mitochondria-based Biosensors in Microfluidic DevicesF32GM067445 · NIGMS · HARVARD UNIVERSITY · PI WEIBEL, DOUGLAS BENJAMIN · 2003 to 2004
$89k
Avidity and Flexibility in Antibody RecognitionF32AI057076 · NIAID · HARVARD UNIVERSITY · PI URBACH, ADAM ROBERT · 2003 to 2003
$42k
NIAID NIH HHS AI057076NIAID NIH HHS F32 AI057076NIGMS NIH HHS F32 GM067445NIGMS NIH HHS GM067445NIGMS NIH HHS GM30367NIGMS NIH HHS GM51559NIGMS NIH HHS R01 GM030367NIGMS NIH HHS R01 GM051559NIGMS NIH HHS R37 GM030367
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acid SequenceAnimalsCarbonic AnhydrasesHumansIsoenzymesLigandsModels, MolecularMolecular Sequence DataProtein BindingSequence AlignmentStructure-Activity RelationshipCarbonic AnhydrasesIsoenzymesLigands

Identifiers

PMID18335973
PMCPMC2740730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.