ArticleVirchows Archiv : an international journal of pathology2008
Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks.
Article in Virchows Archiv : an international journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Molecular background of the regional lymph node metastasis of gastric cancer.Oncology letters · 2018Review
- Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway.World journal of gastroenterology · 2015Article
- Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk.Medical microbiology and immunology · 2013Review
- Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation.Carcinogenesis · 2013Review
- DNA and histone methylation in gastric carcinogenesis.World journal of gastroenterology · 2013Review
- Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications.Clinical epigenetics · 2011Article
- Review
- CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features.Virchows Archiv : an international journal of pathology · 2010Article
- Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer.Virchows Archiv : an international journal of pathology · 2010Article
- Mixed-type gastric cancer and its association with high-frequency CpG island hypermethylation.Virchows Archiv : an international journal of pathology · 2010Article
- Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers.Virchows Archiv : an international journal of pathology · 2009Article
- DNA methylation and expression patterns of key tissue-specific genes in adult stem cells and stomach tissues.Journal of Korean medical science · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection can induce CpG island (CGI) hypermethylation in gastric mucosa. Recently, genes occupied by Polycomb proteins in embryonic stem cells were shown to be vulnerable to aberrant DNA hypermethylation in cancers. To explore the relationship between H. pylori infection and DNA methylation changes in neoplastic and non-neoplastic stomach, we analyzed 25 CGIs and repetitive DNA elements from 82 chronic gastritis and 69 gastric carcinomas. Twenty-three CGIs showed significantly higher methylation levels in H. pylori-negative gastric carcinoma (n = 28) than in H. pylori-negative chronic gastritis (n = 39; P < 0.05), indicating cancer-associated methylation. Eight CGIs exhibited significantly higher methylation levels in H. pylori-positive chronic gastritis (n = 43) than in H. pylori-negative chronic gastritis (n = 39; P < 0.05). Six CGIs showed both cancer-associated and H. pylori-associated hypermethylation. Six (75%) of the eight H. pylori-associated hypermethylated genes contained at least one of three repressive marks (Suzl2 occupancy, Eed occupancy, histone H3 K27 trimethylation), whereas 31% of the remaining cancer-associated hypermethylated genes had at least one mark. The findings suggest that H. pylori infection strongly induces CGI hypermethylation in gastric epithelial cells and that susceptibility to H. pylori-induced DNA hypermethylation may be determined by Polycomb repressive marks in stem or progenitor cells.
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