ArticlePflugers Archiv : European journal of physiology2008
Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Revisiting voltage-coupled HAmerican journal of physiology. Renal physiology · 2024Review
- Article
- P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb.Acta physiologica (Oxford, England) · 2015Article
- Non-invasive imaging of acute allograft rejection after rat renal transplantation using 18F-FDG PET.Journal of visualized experiments : JoVE · 2013Article
- The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s).Kidney international · 2011Article
- Non-invasive imaging of acute renal allograft rejection in rats using small animal F-FDG-PET.PloS one · 2009Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute rejection in renal transplantation disturbs solute and volume maintenance in humans accompanied by delayed graft function and poor prognosis. We recently reported that decreased expression and function of Na+/H+ exchanger type 3 (NHE-3) in proximal tubules and epithelial Na+ channels and aquaporin 2 in collecting ducts are major mechanisms involved in Na+ and water imbalances shortly after transplantation in rat undergoing acute rejection. We performed kidney transplantations in rats with bilaterally nephrectomized recipients with acute rejection and, in addition, systemically administered a specific inhibitor of NHE-3 (NHE-I). NHE inhibition in acute renal failure was shown to improve tubular function and recovery. The aim of this therapy was to reduce energy consumption of the graft and preserve NHE-3 function. Imbalances in electrolyte excretion declined in NHE-I-treated animals and NHE-3 activity was preserved. Observed NHE-I-dependent changes in electrolyte excretion, polyuria, and reduced protein reabsorption in the acute postoperative phase are predictors of favorable graft outcome in humans.
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