ReviewAnalytical and bioanalytical chemistry2008
Microtechnologies for membrane protein studies.
Review in Analytical and bioanalytical chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Aptamers Targeting Membrane Proteins for Sensor and Diagnostic Applications.Molecules (Basel, Switzerland) · 2023Review
- A Versatile Suspended Lipid Membrane System for Probing Membrane Remodeling and Disruption.Membranes · 2022Article
- Enhanced Stability of Lipid Structures by Dip-Pen Nanolithography on Block-Type MPC Copolymer.Molecules (Basel, Switzerland) · 2020Article
- A Low-Noise Transimpedance Amplifier for BLM-Based Ion Channel Recording.Sensors (Basel, Switzerland) · 2016Article
- Highly parallel transport recordings on a membrane-on-nanopore chip at single molecule resolution.Nano letters · 2014Article
- Constructing droplet interface bilayers from the contact of aqueous droplets in oil.Nature protocols · 2013Article
- Automated parallel recordings of topologically identified single ion channels.Scientific reports · 2013Article
- Formation of lipid bilayers inside microfluidic channel array for monitoring membrane-embedded nanopores of phi29 DNA packaging nanomotor.Biomedical microdevices · 2012Article
- Revisiting lab-on-a-chip technology for drug discovery.Nature reviews. Drug discovery · 2012Review
- Model lipid bilayer with facile diffusion of lipids and integral membrane proteins.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Bilayer edges catalyze supported lipid bilayer formation.Biophysical journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the rapid and enormous progress in biotechnologies, the biochemical analysis of membrane proteins is still a difficult task. The presence of the large hydrophobic region buried in the lipid bilayer membrane (transmembrane domain) makes it difficult to analyze membrane proteins in standard assays developed for water-soluble proteins. To handle membrane proteins, the lipid bilayer membrane may be used as a platform to sustain their functionalities. Relatively slow progress in developing micro total analysis systems (microTAS) for membrane protein analysis directly reflects the difficulty of handling lipid membranes, which is a common problem in bulk measurement technologies. Nonetheless, researchers are continuing to develop efficient and sensitive analytical microsystems for the study of membrane proteins. Here, we review the latest developments, which enable detection of events caused by membrane proteins, such as ion channel current, membrane transport, and receptor/ligand interaction, by utilizing microfabricated structures. High-throughput and highly sensitive detection systems for membrane proteins are now becoming a realistic goal. Although most of these systems are still in the early stages of development, we believe this field will become one of the most important applications of microTAS for pharmaceutical and clinical screenings as well as for basic biochemical research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.