ArticleEnvironmental health perspectives2008
Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Respiratory, hepatic, renal, and hematological disorders among adolescent females environmentally exposed to pesticides, Menoufia governorate, Egypt.Environmental science and pollution research international · 2022Article
- Mini review: Neural mechanisms underlying airway hyperresponsiveness.Neuroscience letters · 2021Review
- Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice.Analytical and bioanalytical chemistry · 2020Article
- Lung eosinophils increase vagus nerve-mediated airway reflex bronchoconstriction in mice.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.American journal of respiratory cell and molecular biology · 2019Article
- Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-Physiological reports · 2017Article
- Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Pesticides are Associated with Allergic and Non-Allergic Wheeze among Male Farmers.Environmental health perspectives · 2017Article
- Protective Role of Eosinophils and TNFa after Ozone Inhalation.Research report (Health Effects Institute) · 2017Article
- The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity.American journal of respiratory cell and molecular biology · 2015Article
- Environmental exposure to pesticides and respiratory health.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Respiratory disease in United States farmers.Occupational and environmental medicine · 2014Article
- Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Lifetime organophosphorous insecticide use among private pesticide applicators in the Agricultural Health Study.Journal of exposure science & environmental epidemiology · 2012Article
- Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.PloS one · 2010Article
- Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.The European respiratory journal · 2009Article
- Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent epidemiologic studies have identified organophosphorus pesticides (OPs) as environmental factors potentially contributing to the increase in asthma prevalence over the last 25 years. In support of this hypothesis, we have demonstrated that environmentally relevant concentrations of OPs induce airway hyperreactivity in guinea pigs.
objectivesSensitization to allergen is a significant contributing factor in asthma, and we have shown that sensitization changes virus-induced airway hyperreactivity from an eosinophil-independent mechanism to one mediated by eosinophils. Here, we determine whether sensitization similarly influences OP-induced airway hyperreactivity.
methodsNonsensitized and ovalbumin-sensitized guinea pigs were injected subcutaneously with the OP parathion (0.001-1.0 mg/kg). Twenty-four hours later, animals were anesthetized and ventilated, and bronchoconstriction was measured in response to either vagal stimulation or intravenous acetylcholine. Inflammatory cells and acetylcholinesterase activity were assessed in tissues collected immediately after physiologic measurements.
resultsOvalbumin sensitization decreased the threshold dose for parathion-induced airway hyperreactivity and exacerbated parathion effects on vagally induced bronchoconstriction. Pretreatment with antibody to interleukin (IL)-5 prevented parathion-induced hyperreactivity in sensitized but not in nonsensitized guinea pigs. Parathion did not increase the number of eosinophils in airways or the number of eosinophils associated with airway nerves nor did it alter eosinophil activation as assessed by major basic protein deposition.
conclusionsAntigen sensitization increases vulnerability to parathion-induced airway hyperreactivity and changes the mechanism to one that is dependent on IL-5. Because sensitization to allergens is characteristic of 50% of the general population and 80% of asthmatics (including children), these findings have significant implications for OP risk assessment, intervention, and treatment strategies.
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