ArticleEnvironmental health perspectives2008
Temporal variation in the association between benzene and leukemia mortality.
Article in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis.Environmental health : a global access science source · 2010Pooled it
- Calculating preventable risk fractions for exposure-reducing interventions.Global epidemiology · 2025Article
- Cancer incidence in a cohort of Swedish merchant seafarers between 1985 and 2011.International archives of occupational and environmental health · 2022Article
- Evaluation of Occupational Health Risk Management and Performance in China: A Case Study of Gas Station Workers.International journal of environmental research and public health · 2022Article
- Review
- Benzene Exposure and Cancer Risk from Commercial Gasoline Station Fueling Events Using a Novel Self-Sampling Protocol.International journal of environmental research and public health · 2021Article
- Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.Journal of the National Cancer Institute · 2019Article
- Global Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels.International journal of environmental research and public health · 2018Article
- Indolent B-Cell Lymphoid Malignancy in the Spleen of a Man Who Handled Benzene: Splenic Marginal Zone Lymphoma.Safety and health at work · 2017Article
- Exposure-response relationships for select cancer and non-cancer health outcomes in a cohort of U.S. firefighters from San Francisco, Chicago and Philadelphia (1950-2009).Occupational and environmental medicine · 2015Article
- Risk of death for hematological malignancies for residents close to an Italian petrochemical refinery: a population-based case-control study.Cancer causes & control : CCC · 2014Article
- Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study.American journal of epidemiology · 2014Article
- Cancer incidence in world trade center rescue and recovery workers, 2001-2008.Environmental health perspectives · 2013Article
- The use of biomonitoring data in exposure and human health risk assessment: benzene case study.Critical reviews in toxicology · 2013Review
- Myelodysplastic syndrome and benzene exposure among petroleum workers: an international pooled analysis.Journal of the National Cancer Institute · 2012Article
- Risk perception and occupational accidents: a study of gas station workers in southern Brazil.International journal of environmental research and public health · 2012Article
- Environmental chemical exposures and human epigenetics.International journal of epidemiology · 2012Article
- Occupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.Environmental health perspectives · 2011Review
- Retrospective benzene exposure assessment for a multi-center case-cohort study of benzene-exposed workers in China.Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundBenzene is a human carcinogen. Exposure to benzene occurs in occupational and environmental settings.
objectiveI evaluated variation in benzene-related leukemia with age at exposure and time since exposure.
methodsI evaluated data from a cohort of 1,845 rubber hydrochloride workers. Benzene exposure-leukemia mortality trends were estimated by applying proportional hazards regression methods. Temporal variation in the impact of benzene on leukemia rates was assessed via exposure time windows and fitting of a multistage cancer model.
resultsThe association between leukemia mortality and benzene exposures was of greatest magnitude in the 10 years immediately after exposure [relative rate (RR) at 10 ppm-years = 1.19; 95% confidence interval (CI), 1.10-1.29]; the association was of smaller magnitude in the period 10 to < 20 years after exposure (RR at 10 ppm-years = 1.05; 95% CI, 0.97-1.13); and there was no evidence of association > or = 20 years after exposure. Leukemia was more strongly associated with benzene exposures accrued at > or = 45 years of age (RR at 10 ppm-years = 1.11; 95% CI, 1.04-1.17) than with exposures accrued at younger ages (RR at 10 ppm-years = 1.01; 95% CI, 0.92-1.09). Jointly, these temporal effects can be efficiently modeled as a multistage process in which benzene exposure affects the penultimate stage in disease induction.
conclusionsFurther attention should be given to evaluating the susceptibility of older workers to benzene-induced leukemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.