ReviewEnvironmental health perspectives2008
Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.
Review in Environmental health perspectives, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis.Human reproduction update · 2016Pooled it
- The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.Frontiers in endocrinology · 2025Review
- Chloroform associated with bone mineral density and bone mineral content in adults: A population-based cross-sectional research.PloS one · 2024Article
- The Association between Long-Term DDT or DDE Exposures and an Altered Sperm Epigenome-a Cross-Sectional Study of Greenlandic Inuit and South African VhaVenda Men.Environmental health perspectives · 2024Article
- Polychlorinated Biphenyls and Semen Quality in Healthy Young Men Living in a Contaminated Area.Toxics · 2023Article
- Article
- Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.Frontiers in public health · 2020Review
- Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).International journal of environmental research and public health · 2018Article
- Factors associated with aberrant imprint methylation and oligozoospermia.Scientific reports · 2017Article
- Health effects associated with measured levels of contaminants in the Arctic.International journal of circumpolar health · 2016Article
- Overview of ongoing cohort and dietary studies in the Arctic.International journal of circumpolar health · 2016Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Persistent organic pollutants and semen quality: The LIFE Study.Chemosphere · 2015Article
- Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.Environmental research · 2015Article
- Serum phthalate levels and time to pregnancy in couples from Greenland, Poland and Ukraine.PloS one · 2015Article
- Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure.International journal of clinical and experimental pathology · 2015Article
- Exposure to endosulfan influences sperm competition in Drosophila melanogaster.Scientific reports · 2014Article
- Exposure to endocrine disrupters and nuclear receptor gene expression in infertile and fertile women from different Italian areas.International journal of environmental research and public health · 2014Article
- Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins.Human reproduction (Oxford, England) · 2014Article
- Exposure to endocrine disrupting chemicals and male reproductive health.Frontiers in public health · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. DATA SYNTHESIS: The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral alpha-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified.
conclusionsPOPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.