ArticlePloS one2008
Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02274805 (Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures
Who cites it
47 citing papers in PubMed, 134 citations in OpenAlex.
- Trial
- Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans.International journal of biometeorology · 2017Trial
- Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus.European journal of nuclear medicine and molecular imaging · 2016Trial
- The thermogenic responses to overfeeding and cold are differentially regulated.Obesity (Silver Spring, Md.) · 2016Trial
- Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance.Diabetologia · 2015Trial
- Article
- Energy expenditure during physical work in cold environments: physiology and performance considerations for military service members.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Article
- Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue.International journal of obesity (2005) · 2023Review
- Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy.BMC biology · 2023Article
- Targeting skeletal muscle mitochondrial health in obesity.Clinical science (London, England : 1979) · 2022Review
- Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss.Obesity (Silver Spring, Md.) · 2022Review
- Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity.Metabolites · 2022Review
- Influences of ovarian hormones on physiological responses to cold in women.Temperature (Austin, Tex.) · 2022Review
- Metabolic responses to mild cold acclimation in type 2 diabetes patients.Nature communications · 2021Article
- Extension of Mitogenome Enrichment Based on Single Long-Range PCR: mtDNAs and Putative Mitochondrial-Derived Peptides of Five Rodent Hibernators.Frontiers in genetics · 2021Article
- Hypoxia gradually augments metabolic and thermoperceptual responsiveness to repeated whole-body cold stress in humans.Experimental physiology · 2020Article
- Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia.Scientific reports · 2020Article
- Seven days of cold acclimation substantially reduces shivering intensity and increases nonshivering thermogenesis in adult humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Identification of potential markers of fatal hypothermia by a body temperature-dependent gene expression assay.International journal of legal medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMild cold exposure and overfeeding are known to elevate energy expenditure in mammals, including humans. This process is called adaptive thermogenesis. In small animals, adaptive thermogenesis is mainly caused by mitochondrial uncoupling in brown adipose tissue and regulated via the sympathetic nervous system. In humans, skeletal muscle is a candidate tissue, known to account for a large part of the epinephrine-induced increase in energy expenditure. However, mitochondrial uncoupling in skeletal muscle has not extensively been studied in relation to adaptive thermogenesis in humans. Therefore we hypothesized that cold-induced adaptive thermogenesis in humans is accompanied by an increase in mitochondrial uncoupling in skeletal muscle. METHODOLOGY/PRINCIPAL
findingsThe metabolic response to mild cold exposure in 11 lean, male subjects was measured in a respiration chamber at baseline and mild cold exposure. Skeletal muscle mitochondrial uncoupling (state 4) was measured in muscle biopsies taken at the end of the respiration chamber stays. Mild cold exposure caused a significant increase in 24h energy expenditure of 2.8% (0.32 MJ/day, range of -0.21 to 1.66 MJ/day, p<0.05). The individual increases in energy expenditure correlated to state 4 respiration (p<0.02, R(2) = 0.50). CONCLUSIONS/SIGNIFICANCE: This study for the first time shows that in humans, skeletal muscle has the intrinsic capacity for cold induced adaptive thermogenesis via mitochondrial uncoupling under physiological conditions. This opens possibilities for mitochondrial uncoupling as an alternative therapeutic target in the treatment of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.