ArticlePloS one2008
The phylogeny of the four pan-American MtDNA haplogroups: implications for evolutionary and disease studies.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90 citing papers in PubMed.
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- Continuity and discontinuity in Native American populations: Insights from ancient and modern mitochondrial DNA.Genetics and molecular biology · 2026Article
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- Mitochondrial DNA control region diversity in a population from Parana state-increasing the Brazilian forensic database.International journal of legal medicine · 2019Article
- Analysis of the human Y-chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas.BMC biology · 2019Article
- Historical records under the genetic evidence: "Chiriguano" tribe genesis as a test case.Molecular biology reports · 2018Article
- The peopling of South America and the trans-Andean gene flow of the first settlers.Genome research · 2018Article
- The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages.Genome biology · 2018Article
- Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina.PloS one · 2018Article
- Tuberculosis in post-contact Native Americans of Brazil: Paleopathological and paleogenetic evidence from the Tenetehara-Guajajara.PloS one · 2018Article
- How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data.Genetics and molecular biology · 2018Article
- Ancient human mitochondrial DNA and radiocarbon analysis of archived quids from the Mule Spring Rockshelter, Nevada, USA.PloS one · 2018Article
- Successful reconstruction of whole mitochondrial genomes from ancient Central America and Mexico.Scientific reports · 2017Article
30 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least amount of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub-haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived clades are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrasts with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
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