ArticlePloS one2008
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 8 of them syntheses that pooled it.
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Who cites it
106 citing papers in PubMed, 8 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Pooled it
- New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.Nature human behaviour · 2019Pooled it
- Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.PloS one · 2014Pooled it
- Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study.BMC medical genetics · 2013Pooled it
- FTO gene variant and risk of overweight and obesity among children and adolescents: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.Diabetologia · 2012Pooled it
- Implication of European-derived adiposity loci in African Americans.International journal of obesity (2005) · 2012Pooled it
- FTO gene polymorphisms and obesity risk: a meta-analysis.BMC medicine · 2011Pooled it
- Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children.BMC medical genetics · 2013Trial
- A Rapid Genotyping Assay forCurrent developments in nutrition · 2026Article
- The genetics of obesity: aetiology, prevention and therapy.Nature metabolism · 2026Review
- Association between Fat Mass and Obesity-Related Transcript Polymorphisms and Osteoporosis Phenotypes.Journal of bone metabolism · 2024Article
- Translation of genome-wide association study: from genomic signals to biological insights.Frontiers in genetics · 2024Review
- Precision Nutrition and Cardiovascular Disease Risk Reduction: the Promise of High-Density Lipoproteins.Current atherosclerosis reports · 2023Review
- "GENYAL" Study to Childhood Obesity Prevention: Methodology and Preliminary Results.Frontiers in nutrition · 2022Article
- Genetics, epigenetics and transgenerational transmission of obesity in children.Frontiers in endocrinology · 2022Review
- Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico.Journal of physiological anthropology · 2021Article
- The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans.Molecular genetics & genomic medicine · 2021Article
- Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases.International journal of molecular sciences · 2021Review
- Genetic Determinants of Childhood Obesity.Molecular diagnosis & therapy · 2020Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians and African Americans (AA). Utilizing data from our ongoing GWA study in our cohort of 418 Caucasian obese children (BMI>or=95th percentile), 2,270 Caucasian controls (BMI<95th percentile), 578 AA obese children and 1,424 AA controls, we investigated the association of the previously reported variation at the FTO locus with the childhood form of this disease in both ethnicities. The minor allele frequencies (MAF) of rs8050136 and rs3751812 (perfect surrogates for rs9939609 i.e. both r(2) = 1) in the Caucasian cases were 0.448 and 0.443 respectively while they were 0.391 and 0.386 in Caucasian controls respectively, yielding for both an odds ratio (OR) of 1.27 (95% CI 1.08-1.47; P = 0.0022). Furthermore, the MAFs of rs8050136 and rs3751812 in the AA cases were 0.449 and 0.115 respectively while they were 0.436 and 0.090 in AA controls respectively, yielding an OR of 1.05 (95% CI 0.91-1.21; P = 0.49) and of 1.31 (95% CI 1.050-1.643; P = 0.017) respectively. Investigating all 13 SNPs present on the Illumina HumanHap550 BeadChip in this region of linkage disequilibrium, rs3751812 was the only SNP conferring significant risk in AA. We have therefore replicated and refined the association in an AA cohort and distilled a tag-SNP, rs3751812, which captures the ancestral origin of the actual mutation. As such, variants in the FTO gene confer a similar magnitude of risk of obesity to children as to their adult counterparts and appear to have a global impact.
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