ArticlePloS one2008
Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 95 citations in OpenAlex.
- Association of the rs1126616 and rs9138 Variants in theInternational journal of molecular sciences · 2024Article
- CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease.BMC genomics · 2023Article
- The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population.Postepy dermatologii i alergologii · 2020Article
- Osteopontin Gene Polymorphism and Urinary OPN Excretion in Patients with Immunoglobulin A Nephropathy.Cells · 2019Article
- The role of osteopontin in kidney diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Review
- The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis.Frontiers in neurology · 2017Article
- Association of the osteopontin rs1126616 polymorphism and a higher serum osteopontin level with lupus nephritis.Biomedical reports · 2016Article
- Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases.Journal of immunology research · 2016Review
- Immunogenetics of systemic lupus erythematosus: A comprehensive review.Journal of autoimmunity · 2015Review
- Role of osteopontin in systemic lupus erythematosus.Archivum immunologiae et therapiae experimentalis · 2014Review
- Modulation of autoimmune rheumatic diseases by oestrogen and progesterone.Nature reviews. Rheumatology · 2014Review
- Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis.World journal of hepatology · 2014Review
- Investigation of osteopontin levels and genomic variation of osteopontin and its receptors in Type 1 diabetes mellitus.Journal of endocrinological investigation · 2013Article
- Genetics of the type I interferon pathway in systemic lupus erythematosus.International journal of clinical rheumatology · 2013Article
- Osteopontin in bone mineral density of very old Brazilians.Journal of bone and mineral metabolism · 2013Article
- Alterations in osteopontin modify muscle size in females in both humans and mice.Medicine and science in sports and exercise · 2013Article
- Late-onset systemic lupus erythematosus-associated primary biliary cirrhosis.International archives of medicine · 2013Article
- An overview of STRUCTURE: applications, parameter settings, and supporting software.Frontiers in genetics · 2013Article
- Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
Osteopontin (SPP1) is an important bone matrix mediator found to have key roles in inflammation and immunity. SPP1 genetic polymorphisms and increased osteopontin protein levels have been reported to be associated with SLE in small patient collections. The present study evaluates association between SPP1 polymorphisms and SLE in a large cohort of 1141 unrelated SLE patients [707 European-American (EA) and 434 African-American (AA)], and 2009 unrelated controls (1309 EA and 700 AA). Population-based case-control association analyses were performed. To control for potential population stratification, admixture adjusted logistic regression, genomic control (GC), structured association (STRAT), and principal components analysis (PCA) were applied. Combined analysis of 2 ethnic groups, showed the minor allele of 2 SNPs (rs1126616T and rs9138C) significantly associated with higher risk of SLE in males (P = 0.0005, OR = 1.73, 95% CI = 1.28-2.33), but not in females. Indeed, significant gene-gender interactions in the 2 SNPs, rs1126772 and rs9138, were detected (P = 0.001 and P = 0.0006, respectively). Further, haplotype analysis identified rs1126616T-rs1126772A-rs9138C which demonstrated significant association with SLE in general (P = 0.02, OR = 1.30, 95%CI 1.08-1.57), especially in males (P = 0.0003, OR = 2.42, 95%CI 1.51-3.89). Subgroup analysis with single SNPs and haplotypes also identified a similar pattern of gender-specific association in AA and EA. GC, STRAT, and PCA results within each group showed consistent associations. Our data suggest SPP1 is associated with SLE, and this association is especially stronger in males. To our knowledge, this report serves as the first association of a specific autosomal gene with human male lupus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.