ArticleMolecular vision2008
Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients.
Article in Molecular vision, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.PloS one · 2013Pooled it
- TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population.Arquivos brasileiros de oftalmologia · 2021Article
- Is pseudoexfoliation glaucoma a neurodegenerative disorder?Journal of biosciences · 2021Review
- Updates on Genes and Genetic Mechanisms Implicated in Primary Angle-Closure Glaucoma.The application of clinical genetics · 2021Review
- Review
- Increased Plasma Levels of 8-Hydroxy-2'-deoxyguanosine (8-OHdG) in Patients with Pseudoexfoliation Glaucoma.Journal of ophthalmology · 2019Article
- Frontiers of Complex Disease Mechanisms: Membrane Surface Tension May Link Genotype to Phenotype in Glaucoma.Frontiers in cell and developmental biology · 2018Article
- Article
- Prevalence of glaucoma in the Israeli Arab population.International journal of ophthalmology · 2018Article
- An Updated Review on the Genetics of Primary Open Angle Glaucoma.International journal of molecular sciences · 2015Review
- Association of total antioxidants level with glaucoma type and severity.Saudi medical journal · 2015Article
- Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma.Iranian journal of basic medical sciences · 2014Article
- Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations.Human genomics · 2012Review
- Age-related macular degeneration and genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1).Molecular biology reports · 2012Article
- Genetics and genomics of pseudoexfoliation syndrome/glaucoma.Middle East African journal of ophthalmology · 2011Article
- Complex genetic mechanisms in glaucoma: an overview.Indian journal of ophthalmology · 2011Review
- Decreased total antioxidants status in the plasma of patients with pseudoexfoliation glaucoma.Molecular vision · 2011Article
- Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?Molecular vision · 2011Article
- The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population.Molecular vision · 2010Article
- MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma.Molecular vision · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGlutathione S-transferases (GSTs) are a family of enzymes that inactivate xenobiotics and endogenous end products formed as secondary metabolites during oxidative stress. In humans, GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) are associated with a variety of pathologic processes including certain ophthalmologic diseases.
methodsWe compared the prevalence of GSTT1 and GSTM1 deletion genotypes, which were determined by multiplex polymerase chain reaction, in 107 Arab patients with glaucoma (49 with primary open-angle glaucoma, 29 with pseudoexfoliation glaucoma, and 29 with primary angle-closure glaucoma) to 120 age, sex, and ethnically matched controls.
resultsAll three GST polymorphisms were significantly more common in the entire glaucoma group (p<0.0167) than in controls. However, when patients were stratified by glaucoma type, the deletion genotype, T0M0, was not particularly associated with any type of glaucoma tested. The T1MO genotype was more common among patients with each type of glaucoma than among controls whereas T0M1 genotype was more common among pseudoexfoliation glaucoma (PEG) and primary open-angle glaucoma (POAG) patients than controls.
conclusionsThe overall results indicate a possible variable association between various GSTT1 and GSTM1 genotypes and glaucoma in this population. Decreased GST function might interfere with the metabolism of oxidative intermediates and exacerbate the direct or indirect damaging effects of oxidative stress on the optic nerve. It is possible that these GST polymorphisms may be risk factors for glaucoma.
Indexed as
Identifiers
18334963PMC2268859W49217403What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.