ArticleIndian journal of pediatrics2008
Spectrum of primary immune deficiency at a tertiary care hospital.
Article in Indian journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pooled it
- Genetic analysis of children with suspected immunodeficiency: mimickers of inborn errors of immunity.European journal of pediatrics · 2026Article
- Clinical and Genetic Spectrum of Inborn Errors of Immunity in a Tertiary Care Center in Southern India.Indian journal of pediatrics · 2022Article
- Clinical and Laboratory Profiles of 17 Cases of Chronic Granulomatous Disease in North India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review.International journal of pediatrics & adolescent medicine · 2020Article
- The spectrum of primary immunodeficiencies at a tertiary care hospital in Pakistan.The World Allergy Organization journal · 2020Article
- The monogenic basis of human tuberculosis.Human genetics · 2020Review
- Primary Immunodeficiency Disorders Among North Indian Children.Indian journal of pediatrics · 2019Article
- Serial Serum Immunoglobulin G (IgG) Trough Levels in Patients with X-linked Agammaglobulinemia on Replacement Therapy with Intravenous Immunoglobulin: Its Correlation with Infections in Indian Children.Journal of clinical immunology · 2017Article
- Clinical, Immunological, and Molecular Findings of Patients with p47Journal of clinical immunology · 2016Article
- Inherited and acquired immunodeficiencies underlying tuberculosis in childhood.Immunological reviews · 2015Review
- X linked agammaglobulinemia: a single centre experience from India.Indian journal of pediatrics · 2014Article
- Chronic granulomatous disease: two decades of experience from a tertiary care centre in North West India.Journal of clinical immunology · 2014Article
- An update on granulomatous diseases of the oral tissues.Dental clinics of North America · 2013Review
- Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India.Journal of clinical immunology · 2013Article
- Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases.The Journal of infection · 2012Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report various primary immune deficiencies diagnosed in children at a tertiary care hospital, their clinical manifestations and laboratory profile.
methodsCase records of children diagnosed to have primary immunodeficiency disorders over a period of 24 months at a tertiary care hospital in northern India were evaluated.
resultsTwenty-seven children (M: F=3.5: 1) with mean age of 5.4 +/- 4.6 yrs (2 mo-16 yr) were diagnosed to have primary immunodeficiency. Thirteen children had chronic granulomatous disease (CGD), 4 had severe combined immunodeficiency (SCID), 4 had hypogammaglobulinemia, 2 had Ataxia telangiectasia, and one each had DiGeorge syndrome, Wiskott Aldrich syndrome, hyper IgM syndrome and leukocyte adhesion defect. Common mode of presentation were recurrent/ persistent pneumonia in 19, recurrent/ persistent diarrhea in 10, deep seated abscesses in 8, allergy in 3, disseminated tuberculosis infection in 2, extensive fungal infections in 2 and 1 each of disseminated cytomegalovirus (CMV) infection, disseminated BCG disease, otitis media and meningitis. Family history of sibling deaths was elicited in 2 families. Infectious agents were isolated in 16 cases.
conclusionFrom a single center 27 patients with primary immune deficiency could be identified by chart review, suggesting need for high index of suspicion for diagnosis of primary immune deficiency in India. Though the exact prevalence is not known there is need to make a registry to document the magnitude of problem of these disorders.
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