ArticleJournal of Alzheimer's disease : JAD2008
Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis.
Article in Journal of Alzheimer's disease : JAD, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Tolfenamic acid reduces tau and CDK5 levels: implications for dementia and tauopathies.Journal of neurochemistry · 2015Article
- Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers.Neuropharmacology · 2014Article
- Infantile exposure to lead and late-age cognitive decline: relevance to AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Article
- Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice.Neurobiology of aging · 2013Article
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- Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain.Brain pathology (Zurich, Switzerland) · 2010Article
- Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Alzheimer's disease is characterized by amyloid-beta peptide (Abeta)-loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor (APP) and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 (SP1), which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene.
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Registered trials
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