ArticleJournal of lipid research2008
Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet.
Article in Journal of lipid research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- A randomized, 12-month, parallel-group trial testing the effects of a cognitive behavioral healthy lifestyle intervention as an adjunct to standard trauma therapy among adults with PTSD: the I-CHAT study protocol.Frontiers in psychology · 2025Article
- Cardiovascular risks in relation to posttraumatic stress severity among young trauma-exposed women.Journal of affective disorders · 2018Article
- Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance.Journal of medical primatology · 2018Article
- The value of extended pedigrees for next-generation analysis of complex disease in the rhesus macaque.ILAR journal · 2013Review
- The baboon kidney transcriptome: analysis of transcript sequence, splice variants, and abundance.PloS one · 2013Article
- Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta).PloS one · 2013Article
- Baboons as a model to study genetics and epigenetics of human disease.ILAR journal · 2013Review
- The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.Nutrition reviews · 2011Review
- Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms.BMC physiology · 2011Article
- Effects of diet on genetic regulation of lipoprotein metabolism in baboons.Atherosclerosis · 2010Article
- Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons.Journal of lipid research · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Both lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity, a biomarker of inflammation, and concentration of its primary associated lipoprotein, LDL, are correlated with adverse coronary outcomes. We previously reported a quantitative trait locus (QTL) corresponding to HSA2p24.3-p23.2 with pleiotropic effects on Lp-PLA(2) activity and LDL-cholesterol (LDL-C) concentration in baboons fed a basal diet. Here, our goal was to locate pleiotropic QTLs influencing both traits in the same baboons fed a high-cholesterol, high-fat (HCHF) diet, and to assess whether shared genetic effects on these traits differ between diets. We assayed Lp-PLA(2) activity and LDL-C concentration in 683 baboons fed the HCHF diet. We used a bivariate maximum likelihood-based variance components approach in whole-genome linkage screens to locate a QTL [logarithm of odds (LOD) = 3.13, genome-wide P = 0.019] corresponding to HSA19q12-q13.2 with pleiotropic effects on Lp-PLA(2) activity and LDL-C levels in the HCHF diet. We additionally found significant evidence of genetic variance in response to diet for Lp-PLA(2) activity (P = 0.0017) and for LDL-C concentration (P = 0.00001), revealing a contribution of genotype-by-diet interaction to covariation in these two traits. We conclude that the pleiotropic QTLs detected at 2p24.3-p23.2 and 19q12-q13.2 on the basal and HCHF diets, respectively, exert diet-specific effects on covariation in Lp-PLA(2) activity and LDL-C concentration.
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