ArticleBMJ (Clinical research ed.)2008
Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control study.
Article in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Cardiovascular Safety and Effectiveness of Bisphosphonates: From Intervention Trials to Real-Life Data.Nutrients · 2022Pooled it
- Alendronate and atrial fibrillation: a meta-analysis of randomized placebo-controlled clinical trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Pooled it
- Bisphosphonates and risk of atrial fibrillation: a meta-analysis.Arthritis research & therapy · 2010Pooled it
- Bisphosphonates and atrial fibrillation: Bayesian meta-analyses of randomized controlled trials and observational studies.BMC musculoskeletal disorders · 2009Pooled it
- Pooled it
- [Austrian guidance for the pharmacological treatment of osteoporosis in postmenopausal women--update 2009].Wiener medizinische Wochenschrift. Supplement · 2009Guideline
- Potential mediators of the mortality reduction with zoledronic acid after hip fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Trial
- A disproportionality analysis of cardiac arrhythmia associated with bisphosphonates based on the FAERS database.Scientific reports · 2025Article
- The Association between Treatment with Bisphosphonates and the Risk of Atrial Fibrillation: A Meta-Analysis of Observational Studies.Korean journal of family medicine · 2022Article
- Incidence and Risk of Venous Thromboembolism in Bisphosphonates and Selective Estrogen Receptor Modulators Treatment in Korea.Journal of Korean medical science · 2021Article
- Review
- Bisphosphonates and cardiovascular risk in elderly patients with previous cardiovascular disease: a population-based nested case-control study in Italy.Therapeutic advances in drug safety · 2019Article
- Role of bisphosphonates in the management of acute Charcot foot.World journal of diabetes · 2018Review
- Observational
- Twelve-Minute Daily Yoga Regimen Reverses Osteoporotic Bone Loss.Topics in geriatric rehabilitation · 2016Article
- Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements.Journal of cardiovascular electrophysiology · 2015Article
- Risk of atrial fibrillation among bisphosphonate users: a multicenter, population-based, Italian study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Observational
- Acute effect of zoledronic acid on the risk of cardiac dysrhythmias.Internal and emergency medicine · 2015Article
- Screening, diagnosis and treatment of osteoporosis: a brief review.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2014Review
- Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays.Canadian family physician Medecin de famille canadien · 2014Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the association between atrial fibrillation and flutter and use of bisphosphonates for osteoporosis among women.
designPopulation based case-control study, using medical databases from Denmark.
settingNorthern Denmark.
participants13 586 patients with atrial fibrillation and flutter and 68 054 population controls, all with complete hospital and prescription history.
main outcome measureAdjusted relative risk of atrial fibrillation and flutter.
results435 cases (3.2%) and 1958 population controls (2.9%) were current users of bisphosphonates for osteoporosis. Etidronate and alendronate were used with almost the same frequency among cases and controls. The adjusted relative risk of current use of bisphosphonates compared with non-use was 0.95 (95% confidence interval 0.84 to 1.07). New users had a relative risk of 0.75 (95% confidence interval 0.49 to 1.16), broadly similar to the estimate for continuing users (relative risk 0.96, 95% confidence interval 0.85 to 1.09). The relative risk estimates were independent of number of prescriptions and the position of the atrial fibrillation and flutter diagnosis in the discharge record, and were similar for inpatients and outpatients.
conclusionNo evidence was found that use of bisphosphonates increases the risk of atrial fibrillation and flutter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.