ArticleBiochemical and biophysical research communications2008
Localization of plasma membrane and secretory calcium pumps in the mammary gland.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 85 citations in OpenAlex.
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- Molecular signature of cadmium-mediated neurodevelopmental disorders in prenatal to postnatal stages.EXCLI journal · 2025Review
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- Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.International journal of molecular sciences · 2022Review
- Increasing serotonin concentrations alter calcium metabolism in periparturient dairy goats.Journal of animal science · 2022Article
- Calcium Signalling in Breast Cancer Associated Bone Pain.International journal of molecular sciences · 2022Review
- The N and C-termini of SPCA2 regulate differently Kv10.1 function: role in the collagen 1-induced breast cancer cell survival.American journal of cancer research · 2021Article
- Calcium Metabolism and Breast Cancer: Echoes of Lactation?Current opinion in endocrine and metabolic research · 2020Article
- Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation.International journal of molecular sciences · 2020Review
- Primary Active CaCold Spring Harbor perspectives in biology · 2020Review
- Serotonin regulates maternal calcium homeostasis during the perinatal period of sheep.Journal of animal science · 2019Article
- An N-terminal CaThe Journal of biological chemistry · 2019Article
- Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.Oncology letters · 2018Article
- Constitutive calcium entry and cancer: updated views and insights.European biophysics journal : EBJ · 2017Review
- Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway CaThe Journal of biological chemistry · 2017Article
- Article
- The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.Scientific reports · 2016Article
- PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Essential role of Orai1 store-operated calcium channels in lactation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology.American journal of physiology. Cell physiology · 2014Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Until recently the mechanism for the enrichment of milk with calcium was thought to be almost entirely via the secretory pathway. However, recent studies suggest that a plasma membrane calcium ATPase, PMCA2, is the primary mechanism for calcium transport into milk, highlighting a major role for apical calcium transport. We compared the expression of the recently identified secretory calcium ATPase, SPCA2, and SPCA1, in the mouse mammary gland during development. SPCA2 levels increased over 35-fold during lactation with expression localized to luminal secretory cells, while SPCA1 increased only a modest 2-fold and was expressed throughout the cells of the mammary gland. We also observed major differences in the localization of PMCA2 and PMCA1. Our studies highlight the likely specific roles of PMCA2 and SPCA2 in lactation and indicate that calcium transport into milk is a complex interplay between apical and secretory pathways.
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