ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2006
Efficacy of antibiotic penetration into pancreatic necrosis.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance.BMC infectious diseases · 2019Guideline
- Antimicrobial therapy for infected necrotizing pancreatitis: microbiology, antimicrobial resistance and pharmacokinetics.The Journal of antimicrobial chemotherapy · 2026Review
- Risk Factors Associated with the Emergence of Multidrug-Resistant Bacteria and Fungal Infections in Walled-Off Pancreatic Necrosis.Antibiotics (Basel, Switzerland) · 2026Article
- Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review.Antibiotics (Basel, Switzerland) · 2024Article
- Infected pancreatic necrosis-Current trends in management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Review
- Effect of early antibiotic treatment strategy on prognosis of acute pancreatitis.BMC gastroenterology · 2023Article
- Antibiotic Utilization in Acute Pancreatitis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Gut Microbiota and Antibiotic Treatments for the Main Non-Oncologic Hepato-Biliary-Pancreatic Disorders.Antibiotics (Basel, Switzerland) · 2023Review
- Diagnosis and Treatment of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2022Review
- 2019 WSES guidelines for the management of severe acute pancreatitis.World journal of emergency surgery : WJES · 2019Review
- Effects of prophylactic antibiotics in acute pancreatitis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Article
- Piperacillin-tazobactam penetration into human pancreatic juice.Antimicrobial agents and chemotherapy · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection of pancreatic necrosis is the most dangerous complication of acute necrotizing pancreatitis. Infection is undoubtedly caused by the endogenous flora of the host. This is why prophylaxis with a broad-spectrum antibiotic is considered an effective procedure. However, two aspects should be taken into consideration when choosing the antibiotic; it should have the spectrum of action consistent with the pathogens and it should penetrate effectively to the necrotic tissue of the pancreas. The aim of the study was to estimate the efficacy of piperacillin/tazobactam penetration into pancreatic necrosis in patients who received intravenous infusion of piperacillin/tazobactam at a dose of 4.5 g every 8 h for 14-21 days, as the prophylaxis in the treatment of acute necrotizing pancreatitis. PATIENTS AND
methodsNecrotic tissue of the pancreas and the inflammatory ascites surrounding the pancreas were derived from 15 patients (male, 10; female, 5; mean age 46 years), who underwent laparatomy due to pancreatic necrosis after treatment for 14-21 days. Tissue/fluid samples were investigated for the concentration of the antibiotic by fluoroscopic/spectroscopic methods of registration in an HPLC system.
resultsThe mean concentration of piperacillin/tazobactam was established as 120 mg/kg (SD+/-34) in the necrotic pancreatic tissue and as 183 mg/kg (SD+/-37) in the inflammatory pancreatic ascites.
conclusionsIn patients with acute necrotizing pancreatitis, the study indicates effective penetration of piperacillin/tazobactam to the necrotic pancreatic tissue and to the inflammatory ascites surrounding the pancreas.
Identifiers
What OpenQuestion holds
Registered trials
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