ArticleMolecular psychiatry2009
A genome-wide association study in 574 schizophrenia trios using DNA pooling.
Article in Molecular psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder.Frontiers in psychiatry · 2025Article
- DRAGON-Data: a platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts.BJPsych open · 2023Article
- Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia.Consortium psychiatricum · 2021Article
- Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs.BMC genomics · 2019Article
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
- Identification and functional studies of regulatory variants responsible for the association ofMolecular neuropsychiatry · 2015Article
- A population-based study of genetic variation and psychotic experiences in adolescents.Schizophrenia bulletin · 2014Article
- Disentangling pooled triad genotypes for association studies.Annals of human genetics · 2014Article
- Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.Schizophrenia bulletin · 2014Article
- A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.Biological psychiatry · 2014Article
- Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Review
- What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn.Molecular psychiatry · 2013Review
- The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants.Molecular psychiatry · 2013Review
- Diverse types of genetic variation converge on functional gene networks involved in schizophrenia.Nature neuroscience · 2012Article
- An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model.Molecular psychiatry · 2012Review
- Involvement of PTPN5, the gene encoding the striatal-enriched protein tyrosine phosphatase, in schizophrenia and cognition.Psychiatric genetics · 2012Article
- Schizophrenia genetics: putting all the pieces together.Current neurology and neuroscience reports · 2012Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The cost of genome-wide association (GWA) studies can be prohibitively high when large samples are genotyped. We conducted a GWA study on schizophrenia (SZ) and to reduce the cost, we used DNA pooling. We used a parent-offspring trios design to avoid the potential problems of population stratification. We constructed pools from 605 unaffected controls, 574 SZ patients and a third pool from all the parents of the patients. We hybridized each pool eight times on Illumina HumanHap550 arrays. We estimated the allele frequencies of each pool from the averaged intensities of the arrays. The significance level of results in the trios sample was estimated on the basis of the allele frequencies in cases and non-transmitted pseudocontrols, taking into account the technical variability of the data. We selected the highest ranked SNPs for individual genotyping, after excluding poorly performing SNPs and those that showed a trend in the opposite direction in the control pool. We genotyped 63 SNPs in 574 trios and analysed the results with the transmission disequilibrium test. Forty of those were significant at P<0.05, with the best result at P=1.2 x 10(-6) for rs11064768. This SNP is within the gene CCDC60, a coiled-coil domain gene. The third best SNP (P=0.00016) is rs893703, within RBP1, a candidate gene for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.