ArticleProceedings of the National Academy of Sciences of the United States of America2008
Bidirectional membrane tube dynamics driven by nonprocessive motors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- MYO1B in human disease: an actin-based motor linking membrane trafficking to oncogenic signaling, metastasis, and vascular aging.Frontiers in oncology · 2026Review
- Article
- Biomembranes undergo complex, non-axisymmetric deformations governed by Kirchhoff-Love kinematicsand revealed by a three-dimensional computational framework.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- Modelling cytoskeletal transport by clusters of non-processive molecular motors with limited binding sites.Royal Society open science · 2020Article
- Mechanisms of Motor-Independent Membrane Remodeling Driven by Dynamic Microtubules.Current biology : CB · 2020Article
- Intracellular cargo transport by single-headed kinesin motors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microparticle Assembly Pathways on Lipid Membranes.Biophysical journal · 2017Article
- Formation of helical membrane tubes around microtubules by single-headed kinesin KIF1A.Nature communications · 2015Article
- Physical principles of membrane remodelling during cell mechanoadaptation.Nature communications · 2015Article
- Building endocytic pits without clathrin.Nature reviews. Molecular cell biology · 2015Review
- Fluorescent quantification of size and lamellarity of membrane nanotubes.European biophysics journal : EBJ · 2014Article
- Reversible membrane pearling in live cells upon destruction of the actin cortex.Biophysical journal · 2014Article
- Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Lipid polymorphisms and membrane shape.Cold Spring Harbor perspectives in biology · 2011Review
- Analytical expressions for the shape of axisymmetric membranes with multiple domains.The European physical journal. E, Soft matter · 2011Article
- Kinesin recycling in stationary membrane tubes.Biophysical journal · 2010Article
- Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1.Molecular biology of the cell · 2010Article
- Nonprocessive motor dynamics at the microtubule membrane tube interface.Biophysical journal · 2010Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In cells, membrane tubes are extracted by molecular motors. Although individual motors cannot provide enough force to pull a tube, clusters of such motors can. Here, we investigate, using a minimal in vitro model system, how the tube pulling process depends on fundamental properties of the motor species involved. Previously, it has been shown that processive motors can pull tubes by dynamic association at the tube tip. We demonstrate that, remarkably, nonprocessive motors can also cooperatively extract tubes. Moreover, the tubes pulled by nonprocessive motors exhibit rich dynamics as compared to those pulled by their processive counterparts. We report distinct phases of persistent growth, retraction, and an intermediate regime characterized by highly dynamic switching between the two. We interpret the different phases in the context of a single-species model. The model assumes only a simple motor clustering mechanism along the length of the entire tube and the presence of a length-dependent tube tension. The resulting dynamic distribution of motor clusters acts as both a velocity and distance regulator for the tube. We show the switching phase to be an attractor of the dynamics of this model, suggesting that the switching observed experimentally is a robust characteristic of nonprocessive motors. A similar system could regulate in vivo biological membrane networks.
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