ArticleProceedings of the National Academy of Sciences of the United States of America2008
Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
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229 citing papers in PubMed.
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- Genomics of Shiga toxin-producing Escherichia coli from asymptomatic carriers in Japan highlights risk-adaptive control.Communications biology · 2025Article
- Effects of bacteriophages on gut microbiome functionality.Gut microbes · 2025Review
- Quantitative analysis of 2-methoxy-3,5-dimethylpyrazine as an earthy-musty off-odor compound in drinking water using HS-SPME-GC-MS.Food science and biotechnology · 2025Article
- Genomic Characterization of Escherichia coli O157:H7 Associated with Multiple Sources, United States.Emerging infectious diseases · 2025Article
- Antimicrobial susceptibility, biofilm formation, and virulence genes among atypical enteropathogenicIranian journal of microbiology · 2025Article
- Shiga Toxin-ProducingMicroorganisms · 2024Article
- Synthetic phage-based approach for sensitive and specific detection of Escherichia coli O157.Communications biology · 2024Article
- Pathogenomes of Shiga Toxin Positive and NegativeMicroorganisms · 2024Article
- In Silico Analysis of Shiga Toxin-ProducingToxins · 2024Article
- Untangling the role of environmental and host-related determinants for on-farm transmission of verotoxin-producingInfection ecology & epidemiology · 2024Article
- Comparative analyses of persistence traits inFrontiers in microbiology · 2024Article
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- The diverse landscape of AB5-type toxins.Engineering microbiology · 2023Review
- Genome-wide association study of hemolytic uremic syndrome causing Shiga toxin-producing Escherichia coli from Sweden, 1994-2018.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Whole-Genome Sequencing of Shiga Toxin-ProducingMicroorganisms · 2023Article
- Alteration of a Shiga toxin-encoding phage associated with a change in toxin production level and disease severity inMicrobial genomics · 2023Article
- A quantitative prevalence ofFood science & nutrition · 2023Article
- Article
169 more citing papers are in PubMed but not listed here.
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14 authors.
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Abstract
Escherichia coli O157:H7, a toxin-producing food and waterborne bacterial pathogen, has been linked to large outbreaks of gastrointestinal illness for more than two decades. E. coli O157 causes a wide range of clinical illness that varies by outbreak, although factors that contribute to variation in disease severity are poorly understood. Several recent outbreaks involving O157 contamination of fresh produce (e.g., spinach) were associated with more severe disease, as defined by higher hemolytic uremic syndrome and hospitalization frequencies, suggesting that increased virulence has evolved. To test this hypothesis, we developed a system that detects SNPs in 96 loci and applied it to >500 E. coli O157 clinical strains. Phylogenetic analyses identified 39 SNP genotypes that differ at 20% of SNP loci and are separated into nine distinct clades. Differences were observed between clades in the frequency and distribution of Shiga toxin genes and in the type of clinical disease reported. Patients with hemolytic uremic syndrome were significantly more likely to be infected with clade 8 strains, which have increased in frequency over the past 5 years. Genome sequencing of a spinach outbreak strain, a member of clade 8, also revealed substantial genomic differences. These findings suggest that an emergent subpopulation of the clade 8 lineage has acquired critical factors that contribute to more severe disease. The ability to detect and rapidly genotype O157 strains belonging to such lineages is important and will have a significant impact on both disease diagnosis and treatment guidelines.
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