ArticleThe Journal of cell biology2008
Myoblasts and macrophages share molecular components that contribute to cell-cell fusion.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 123 citations in OpenAlex.
- Magnetoactive Nanotopography on Hydrogels for Stimulated Cell Adhesion and Differentiation.Small science · 2025Article
- Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration.International journal of molecular sciences · 2023Article
- Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.Scientific reports · 2021Article
- Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC.International journal of molecular sciences · 2020Review
- Transient and Stable Overexpression of Extracellular Superoxide Dismutase Is Positively Associated with the Myogenic Function of Human Skeletal Muscle-Derived Stem/Progenitor Cells.Antioxidants (Basel, Switzerland) · 2020Article
- Cell fusion is differentially regulated in zebrafish post-embryonic slow and fast muscle.Developmental biology · 2020Article
- Tumor-Cell-Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer.International journal of molecular sciences · 2020Review
- Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.American journal of human genetics · 2019Article
- The fusogenic synapse at a glance.Journal of cell science · 2019Review
- Biomechanical Microenvironment Regulates Fusogenicity of Breast Cancer Cells.ACS biomaterials science & engineering · 2019Article
- Adult stem cells at work: regenerating skeletal muscle.Cellular and molecular life sciences : CMLS · 2019Review
- Involvement of Actin Cytoskeletal Components in Breast Cancer Cell Fusion with Human Mesenchymal Stroma/Stem-Like Cells.International journal of molecular sciences · 2019Article
- Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region.Journal of cellular physiology · 2018Article
- The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.Nature communications · 2018Article
- Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells.Developmental cell · 2018Article
- Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC).Cell communication and signaling : CCS · 2018Article
- Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles.Annual review of physiology · 2017Review
- The chicken embryo as an efficient model to test the function of muscle fusion genes in amniotes.PloS one · 2017Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cell-cell fusion is critical to the normal development of certain tissues, yet the nature and degree of conservation of the underlying molecular components remains largely unknown. Here we show that the two guanine-nucleotide exchange factors Brag2 and Dock180 have evolutionarily conserved functions in the fusion of mammalian myoblasts. Their effects on muscle cell formation are distinct and are a result of the activation of the GTPases ARF6 and Rac, respectively. Inhibition of ARF6 activity results in a lack of physical association between paxillin and beta(1)-integrin, and disruption of paxillin transport to sites of focal adhesion. We show that fusion machinery is conserved among distinct cell types because Dock180 deficiency prevented fusion of macrophages and the formation of multinucleated giant cells. Our results are the first to demonstrate a role for a single protein in the fusion of two different cell types, and provide novel mechanistic insight into the function of GEFs in the morphological maturation of multinucleated cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.