ReviewThe Journal of experimental medicine2008
Fixing DNA breaks during class switch recombination.
Review in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair.Trends in microbiology · 2022Review
- IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- The balancing act of R-loop biology: The good, the bad, and the ugly.The Journal of biological chemistry · 2020Review
- Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.Methods in molecular biology (Clifton, N.J.) · 2019Article
- VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells.Oncotarget · 2018Article
- Interaction of DNA repair gene polymorphisms and aflatoxin B1 in the risk of hepatocellular carcinoma.International journal of clinical and experimental pathology · 2014Article
- Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire.Frontiers in immunology · 2013Review
- Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Increased Artemis levels confer radioresistance to both high and low LET radiation exposures.Radiation oncology (London, England) · 2012Article
- B cell TLRs and induction of immunoglobulin class-switch DNA recombination.Frontiers in bioscience (Landmark edition) · 2012Review
- Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase.The Journal of experimental medicine · 2012Article
- Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.PLoS genetics · 2011Article
- Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo.Nucleic acids research · 2010Article
- The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients.Journal of clinical immunology · 2010Article
- Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications.Current genomics · 2010Article
- Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses.Critical reviews in immunology · 2010Review
- Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.