ArticleThe Journal of biological chemistry2008
Annexin A2 interactions with Rab14 in alveolar type II cells.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Epidermal Growth Factor Stimulates Fatty Acid Synthesis Mainly via PLC-γ1/Akt Signaling Pathway in Dairy Goat Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2020Article
- Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing.Cell reports · 2020Article
- CHML promotes liver cancer metastasis by facilitating Rab14 recycle.Nature communications · 2019Article
- An improved Tet-on system in microRNA overexpression and CRISPR/Cas9-mediated gene editing.Journal of animal science and biotechnology · 2019Article
- Inflammation-induced upregulation of P2XAmerican journal of physiology. Lung cellular and molecular physiology · 2019Article
- ATP is stored in lamellar bodies to activate vesicular P2XThe Journal of general physiology · 2018Article
- Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42.Scientific reports · 2016Article
- Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Annexin A2 heterotetramer: structure and function.International journal of molecular sciences · 2013Article
- Physical and functional interaction between the ID1 and p65 for activation of NF-κB.American journal of physiology. Cell physiology · 2012Article
- MicroRNAs and lung cancers: from pathogenesis to clinical implications.Frontiers of medicine · 2012Review
- Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Loss of Rab27 function results in abnormal lung epithelium structure in mice.American journal of physiology. Cell physiology · 2011Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Annexin A2, a calcium-dependent phospholipid-binding protein, is abundantly expressed in alveolar type II cells where it plays a role in lung surfactant secretion. Nevertheless, little is known about the details of its cellular pathways. To identify annexin A2-regulated or associated proteins, we silenced endogenous annexin A2 expression in rat alveolar type II cells by RNA interference and assessed the change of the cellular transcriptome by DNA microarray analysis. The loss of annexin A2 resulted in the change of 61 genes. Thirteen of the selected genes (11 down-regulated and 2 up-regulated genes) were validated by real time quantitative PCR. When the loss of rat annexin A2 was rescued by overexpressing EGFP-tagged human annexin A2, six of seven selected targets returned to their normal expression level, indicating that these genes are indeed annexin A2-associated targets. One of the targets, Rab14, co-immunoprecipitated with annexin A2. Rab14 also co-localized in part with annexin A2 and lamellar bodies in alveolar type II cells. The silencing of Rab14 resulted in a decrease in surfactant secretion, suggesting that Rab14 may play a role in surfactant secretion.
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Registered trials
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