ArticleMolecular and cellular biology2008
Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Novel Splice Variant in theDiagnostics (Basel, Switzerland) · 2025Article
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- TGFβ signaling is required for sclerotome resegmentation during development of the spinal column in Gallus gallus.Developmental biology · 2022Article
- Clinical genetics of spondylocostal dysostosis: A mini review.Frontiers in genetics · 2022Review
- IncreasedJournal of medical genetics · 2020Article
- Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation.Cell reports · 2019Article
- HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development.PLoS genetics · 2019Article
- Mitotic chromosome binding predicts transcription factor properties in interphase.Nature communications · 2019Article
- Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.The International journal of developmental biology · 2019Article
- Arabidopsis Group IIId ERF proteins positively regulate primary cell wall-type CESA genes.Journal of plant research · 2019Article
- Development of the axial skeleton and intervertebral disc.Current topics in developmental biology · 2019Review
- A loss-of-function mutation p.T52S in RIPPLY3 is a potential predisposing genetic risk factor for Chinese Han conotruncal heart defect patients without the 22q11.2 deletion/duplication.Journal of translational medicine · 2018Article
- IVD Development: Nucleus pulposus development and sclerotome specification.Current molecular biology reports · 2018Article
- Presomitic mesoderm-specific expression of the transcriptional repressorThe Journal of biological chemistry · 2018Article
- Article
- Voluntary exposure to a toxin: the genetic influence on ethanol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex.International journal of biological sciences · 2018Article
- tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Function of the C. elegans T-box factor TBX-2 depends on interaction with the UNC-37/Groucho corepressor.Developmental biology · 2016Article
- Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T-box family of transcription factors, defined by a conserved DNA binding domain called the T-box, regulate various aspects of embryogenesis by activating and/or repressing downstream genes. In spite of the biological significance of the T-box proteins, how they regulate transcription remains to be elucidated. Here we show that the Groucho/TLE-associated protein Ripply converts T-box proteins from activators to repressors. In cultured cells, zebrafish Ripply1, an essential component in somite segmentation, and its structural relatives, Ripply2 and -3, suppress the transcriptional activation mediated by the T-box protein Tbx24, which is coexpressed with ripply1 during segmentation. Ripply1 associates with Tbx24 and converts it to a repressor. Ripply1 also antagonizes the transcriptional activation of another T-box protein, No tail (Ntl), the zebrafish ortholog of Brachyury. Furthermore, injection of a high dosage of ripply1 mRNA into zebrafish eggs causes defective development of the posterior trunk, similar to the phenotype observed in homozygous mutants of ntl. A mutant form of Ripply1 defective in association with Tbx24 also lacks activity in zebrafish embryos. These results indicate that the intrinsic transcriptional property of T-box proteins is controlled by Ripply family proteins, which act as specific adaptors that recruit the global corepressor Groucho/TLE to T-box proteins.
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