ArticleMolecular and cellular biology2008
Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Stephanoside B modulates metabolic gene expression and lengthens the circadian bmal1 oscillation period in differentiated myotubes revealed by real-time bioluminescence.Molecular biology reports · 2026Article
- Natural Compounds that Modulate Circadian Rhythms.Current topics in medicinal chemistry · 2025Review
- Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency.PLoS genetics · 2023Article
- Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis.Diabetes · 2022Article
- β-Arrestin 1 (ARRB1) serves as a molecular marker of the peripheral circadian rhythm.International journal of oral science · 2019Article
- Article
- Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium.The Journal of biological chemistry · 2017Article
- Epigenetic regulation of the circadian clock: role of 5-aza-2'-deoxycytidine.Bioscience reports · 2017Article
- Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1.The Journal of biological chemistry · 2013Article
- Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period.Nucleic acids research · 2012Article
- SAF-A has a role in transcriptional regulation of Oct4 in ES cells through promoter binding.Cellular reprogramming · 2011Article
- SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription.PloS one · 2011Article
- Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).The Journal of biological chemistry · 2010Article
- The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.Development (Cambridge, England) · 2010Article
- Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.Nucleic acids research · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Bmal1 is a key component of the mammalian clock system, little is understood about the actual mechanism of circadian Bmal1 gene transcription, particularly at the chromatin level. Here we discovered a unique chromatin structure within the Bmal1 promoter. The RORE region, which is a critical cis element for the circadian regulation of the Bmal1 gene, is comprised of GC-rich open chromatin. The 3'-flanking region of the promoter inhibited rhythmic transcription in the reporter gene assay in vitro even in the presence of RORalpha and REV-ERBalpha. We also found that the nuclear matrix protein SAF-A binds to the 3'-flanking region with circadian timing, which was correlated with Bmal1 expression by footprinting in vivo. These results suggest that the unique chromatin structure containing SAF-A is required for the circadian transcriptional regulation of the Bmal1 gene in cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.