Trial reportFertility and sterility2009
Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome.
Trial report in Fertility and sterility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05428566 (A Comparison of a Pulse-Based Diet and the Therapeutic Lifestyle Changes Diet on Reproductive and Metabolic Parameters in Women with Polycystic Ovary Syndrome), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparison of a Pulse-Based Diet and the Therapeutic Lifestyle Changes Diet on Reproductive and Metabolic Parameters in Women with Polycystic Ovary Syndrome
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimizing carbohydrate quality: a path to better health for women with PCOS.Frontiers in nutrition · 2025Pooled it
- Racial influence on the polycystic ovary syndrome phenotype: a black and white case-control study.Fertility and sterility · 2011Trial
- Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study.Fertility and sterility · 2011Trial
- The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study.Fertility and sterility · 2011Trial
- Reduction in the Free Androgen Index in Overweight Women After Sixty Days of a Low Glycemic Diet.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024Article
- Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period.Cureus · 2023Article
- Lifestyle management in polycystic ovary syndrome - beyond diet and physical activity.BMC endocrine disorders · 2023Review
- Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients.Frontiers in nutrition · 2022Article
- Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome.Nutrients · 2021Observational
- Low intakes of dietary fiber and magnesium are associated with insulin resistance and hyperandrogenism in polycystic ovary syndrome: A cohort study.Food science & nutrition · 2019Article
- High-Fat Diet and Female Fertility.Endocrinology · 2017Review
- The Association of the Dietary Fat and Functional Ovarian Cysts in Women of Reproductive Age Referring to Three Hospitals in Mashhad, Iran, 2014.International journal of community based nursing and midwifery · 2016Article
- Anti-Inflammatory Dietary Combo in Overweight and Obese Women with Polycystic Ovary Syndrome.North American journal of medical sciences · 2015Article
- Obesity and PCOS: implications for diagnosis and treatment.Seminars in reproductive medicine · 2012Review
- Obesity and polycystic ovary syndrome.Obesity facts · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveTo determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS).
designRandomized, crossover design.
settingAcademic research center. PATIENT(S): Fifteen women with PCOS. INTERVENTION(S): We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber). MAIN OUTCOME MEASURE(S): Change in T levels. RESULT(S): Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%-10% within 2-3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals.
conclusionsDiet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.