ReviewDevelopmental cell2008
Intron delays and transcriptional timing during development.
Review in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The transcriptional trajectories of pluripotency and differentiation comprise genes with antithetical architecture and repetitive-element content.BMC biology · 2021Pooled it
- Convergent genome streamlining accompanies independent miniaturization in the world's smallest fishes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Telomere-to-telomere genome ofHorticulture research · 2026Article
- When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF.International journal of molecular sciences · 2026Review
- Cell type-independent timekeeping gene modules enable embryonic stage prediction in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- AMHY and sex determination in egg-laying mammals.Genome biology · 2025Article
- Genome-wide identification of the Medicago sativa L. MYB family and its transcriptional dynamics during pollen development.BMC plant biology · 2025Article
- Control of cell state transitions by post-transcriptional regulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Parallel gene size and isoform expansion of ancient neuronal genes.Current biology : CB · 2024Article
- Amphibian Segmentation Clock Models Suggest How Large Genome and Cell Sizes Slow Developmental Rate.Integrative organismal biology (Oxford, England) · 2024Article
- Genome-wide identification of GH9 gene family and the assessment of its role during fruit abscission zone formation in Vaccinium ashei.Plant cell reports · 2023Article
- Transcript accumulation rates in the earlyScience advances · 2023Article
- STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.Nature communications · 2022Article
- Chromosome-Scale Assembly of theFrontiers in genetics · 2022Article
- Generation and timing of graded responses to morphogen gradients.Development (Cambridge, England) · 2021Article
- Imaging developmental cell cycles.Biophysical journal · 2021Review
- Chromosome-scale assembly of the Dendrobium chrysotoxum genome enhances the understanding of orchid evolution.Horticulture research · 2021Article
- Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering.eLife · 2021Article
- Incorporating age and delay into models for biophysical systems.Physical biology · 2021Article
- Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The time taken to transcribe most metazoan genes is significant because of the substantial length of introns. Developmentally regulated gene networks, where timing and dynamic patterns of expression are critical, may be particularly sensitive to intron delays. We revisit and comment on a perspective last presented by Thummel 16 years ago: transcriptional delays may contribute to timing mechanisms during development. We discuss the presence of intron delays in genetic networks. We consider how delays can impact particular moments during development, which mechanistic attributes of transcription can influence them, how they can be modeled, and how they can be studied using recent technological advances as well as classical genetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.