ArticleMolecular microbiology2008
RosE represses Std fimbrial expression in Salmonella enterica serotype Typhimurium.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Crystal Structure and Functional Characterization of YjgK From Salmonella Typhimurium.Proteins · 2025Article
- Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems.Journal of nanobiotechnology · 2022Review
- Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch.PLoS genetics · 2018Article
- Functional expression of the entire adhesiome of Salmonella enterica serotype Typhimurium.Scientific reports · 2017Article
- Epithelial glycosylation in gut homeostasis and inflammation.Nature immunology · 2016Review
- Exploitation of a "hockey-puck" phenotype to identify pilus and biofilm regulators in Serratia marcescens through genetic analysis.Canadian journal of microbiology · 2016Article
- Transcriptional Profiling of a Cross-ProtectivePathogens (Basel, Switzerland) · 2014Article
- Interactions of Salmonella with animals and plants.Frontiers in microbiology · 2014Review
- Role of StdA in adhesion of Salmonella enterica serovar Enteritidis phage type 8 to host intestinal epithelial cells.Gut pathogens · 2013Article
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation.Clinical microbiology reviews · 2013Review
- Article
- Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence.Infection and immunity · 2012Article
- Novel mycobacteria antigen 85 complex binding motif on fibronectin.The Journal of biological chemistry · 2012Article
- More than one way to control hair growth: regulatory mechanisms in enterobacteria that affect fimbriae assembled by the chaperone/usher pathway.Journal of bacteriology · 2011Review
- Manganese binds to Clostridium difficile Fbp68 and is essential for fibronectin binding.The Journal of biological chemistry · 2011Article
- Dam methylation controls O-antigen chain length in Salmonella enterica serovar enteritidis by regulating the expression of Wzz protein.Journal of bacteriology · 2009Article
- Life in the inflamed intestine, Salmonella style.Trends in microbiology · 2009Review
- Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.FEMS microbiology reviews · 2009Review
- Comparative analysis of attachment of Shiga-toxigenic Escherichia coli and Salmonella strains to cultured HT-29 and Caco-2 cell lines.Applied and environmental microbiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Salmonella enterica serotype Typhimurium (S. typhimurium) genome contains a large repertoire of putative fimbrial operons that remain poorly characterized because they are not expressed in vitro. In this study, insertions that induced expression of the putative stdABCD fimbrial operon were identified from a random bank of transposon mutants by screening with immuno-magnetic particles for ligand expression (SIMPLE). Transposon insertions upstream of csgC and lrhA or within dam, setB and STM4463 (renamed rosE) resulted in expression of StdA and its assembly into fimbrial filaments on the cell surface. RosE is a novel negative regulator of Std fimbrial expression as indicated by its repression of a std::lacZ reporter construct and by binding of the purified protein to a DNA region upstream of the stdA start codon. Expression of Std fimbriae in the rosE mutant resulted in increased attachment of S. typhimurium to human colonic epithelial cell lines (T-84 and CaCo-2). A rosE mutant exhibited a reduced ability to compete with virulent S. typhimurium for colonization of murine organs, while no defect was observed when both competing strains carried a stdAB deletion. These data suggest that a tight control of Std fimbrial expression mediated by RosE is required during host pathogen interaction.
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