ArticleJournal of the American Geriatrics Society2008
Associations between vitamin D status and pain in older adults: the Invecchiare in Chianti study.
Article in Journal of the American Geriatrics Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- A systematic review of vitamin D status in southern European countries.European journal of nutrition · 2018Pooled it
- The association between vitamin D concentration and pain: a systematic review and meta-analysis.Public health nutrition · 2018Pooled it
- Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.Maturitas · 2015Trial
- Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the women's health initiative randomized trial.Journal of the Academy of Nutrition and Dietetics · 2013Trial
- Analgesic effect of raloxifene on back and knee pain in postmenopausal women with osteoporosis and/or osteoarthritis.Journal of bone and mineral metabolism · 2010Trial
- Assessment of Vitamin D Levels in Patients Presenting With Chronic Low Back Pain at a Tertiary Care Hospital.Cureus · 2020Article
- Article
- Evaluation of vitamin D levels in patients with chronic low back-leg pain.Acta orthopaedica et traumatologica turcica · 2017Article
- Is Hypovitaminosis D Associated with Stress Perception in the Elderly? A Nationwide Representative Study in Korea.Nutrients · 2016Article
- No association between level of vitamin D and chronic low back pain in Swedish primary care: a cross-sectional case-control study.Scandinavian journal of primary health care · 2016Article
- Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- The association between chronic pain and obesity.Journal of pain research · 2015Review
- Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.Current pharmaceutical design · 2014Review
- Sports health benefits of vitamin d.Sports health · 2012Review
- Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study.Journal of the American Geriatrics Society · 2012Article
- Utility of geriatric assessment tools to identify 85-years old subjects with vitamin D deficiency.The journal of nutrition, health & aging · 2011Article
- Serum 25-hydroxyvitamin D and depressive symptoms in older women and men.The Journal of clinical endocrinology and metabolism · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo examine cross-sectional associations between vitamin D status and musculoskeletal pain and whether they differ by sex.
designPopulation-based study of persons living in the Chianti geographic area (Tuscany, Italy).
settingCommunity.
participantsNine hundred fifty-eight persons (aged > or = 65) selected from city registries of Greve and Bagno a Ripoli. MEASUREMENTS: Pain was categorized as mild or no pain in the lower extremities and back; moderate to severe back pain, no lower extremity pain; moderate to severe lower extremity pain, no back pain; and moderate to severe lower extremity and back pain (dual region). Vitamin D was measured according to radioimmunoassay, and deficiency was defined as 25-hydroxyvitamin D (25(OH)D) less than 25 nmol/L.
resultsThe mean age+/-standard deviation was 75.1+/-7.3 for women and 73.9+/-6.8 for men. Fifty-eight percent of women had at least moderate pain in some location, compared with 27% of men. After adjusting for potential confounders, vitamin D deficiency was not associated with lower extremity pain or dual-region pain, although it was associated with a significantly higher prevalence of at least moderate back pain without lower extremity pain in women (odds ratio=1.96, 95% confidence interval=1.01-3.59) but not in men.
conclusionLower concentrations of 25(OH)D are associated with significant back pain in older women but not men. Because vitamin D deficiency and chronic pain are fairly prevalent in older adults, these findings suggest it may be worthwhile to query older adults about their pain and screen older women with significant back pain for vitamin D deficiency.
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Registered trials
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