Trial reportThe journal of sexual medicine2008
The inhibitory effects of nicotine on physiological sexual arousal in nonsmoking women: results from a randomized, double-blind, placebo-controlled, cross-over trial.
Trial report in The journal of sexual medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 59 citations in OpenAlex.
- Sexual dysfunction and drug use in women: A reciprocal etiologic relationshipRevista colombiana de obstetricia y ginecologia · 2021Article
- Lifestyles and sexuality in men and women: the gender perspective in sexual medicine.Reproductive biology and endocrinology : RB&E · 2020Review
- Dose-response relationship between cigarette smoking and female sexual dysfunction.Obstetrics & gynecology science · 2015Article
- Telling truth from Ys: an evaluation of whether the accuracy of self-reported semen exposure assessed by a semen Y-chromosome biomarker predicts pregnancy in a longitudinal cohort study of pregnancy.Sexually transmitted infections · 2014Article
- Chronic stress and sexual function in women.The journal of sexual medicine · 2013Article
- Female sexual dysfunction in patients with substance-related disorders.Clinics (Sao Paulo, Brazil) · 2013Article
- Acute exercise improves physical sexual arousal in women taking antidepressants.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2012Article
- Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain.Frontiers in pharmacology · 2012Article
- Evidence for a curvilinear relationship between sympathetic nervous system activation and women's physiological sexual arousal.Psychophysiology · 2012Article
- Emotional dysregulation: concurrent relation to sexual problems among trauma-exposed adult cigarette smokers.Journal of sex & marital therapy · 2010Article
- Lifestyle Choices Can Augment Female Sexual Well-Being.American journal of lifestyle medicineArticle
- Association between cigarette smoking and erectile tumescence: the mediating role of heart rate variability.International journal of impotence researchArticle
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionExtensive research suggests that long-term cigarette smoking is an independent risk factor for the introduction of sexual dysfunction in men. However, results of limited data investigating this relationship in women are mixed. No studies have examined the acute effects of tobacco or nicotine on physiological sexual response in women. Controlled experimental studies examining acute effects of isolated nicotine intake on female physiological sexual responses are necessary in order to help elucidate tobacco's potential role in the development and/or maintenance of sexual impairment in women.
aimTo examine whether isolated nicotine intake acutely affects sexual arousal responses in nonsmoking women.
methodsTwenty-five sexually functional women (mean age = 20 years) each with less than 100 direct exposures to nicotine completed two counterbalanced conditions in which they were randomized to received either nicotine gum (6 mg) or placebo gum, both administered double-blind and matched for appearance, taste, and consistency, approximately 40 minutes prior to viewing an erotic film.
main outcome measuresPhysiological (changes in vaginal pulse amplitude via vaginal photoplethysmography) and subjective (continuous self-report) sexual responses to erotic stimuli were examined, as well as changes in mood.
resultsNicotine significantly reduced genital responses to the erotic films (P = 0.05), corresponding to a 30% attenuation in physiological sexual arousal. This occurred in 11 of 18 women with valid physiological assessments. Nicotine had no significant effect on continuous self-report ratings of sexual arousal (P = 0.45), or on mood (all Ps > 0.05).
conclusionsAcute nicotine intake significantly attenuates physiological sexual arousal in healthy nonsmoking women. Our findings provide support to the hypothesis that nicotine may be the primary pharmacological agent responsible for genital hemodynamic disruption, thereby facilitating a cascade of biochemical and vascular events which may impair normal sexual arousal responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.