ReviewExpert review of medical devices2008
Biological effects of dynamic shear stress in cardiovascular pathologies and devices.
Review in Expert review of medical devices, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Chronic In Vivo Biostability and Biocompatibility Evaluation of Polyether-Urethane-Based Balloon Implants for Cardiac Application in a Porcine Model.Bioengineering (Basel, Switzerland) · 2026Article
- Automated Suture Securing Technology in Mitral Valve Surgery: A Strategy to Reduce Prosthetic Dehiscence?European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Platelet activation via dynamic conformational changes of von Willebrand factor under shear.PloS one · 2020Article
- Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator.Scientific reports · 2019Observational
- Microfluidic flow-based platforms for induction and analysis of dynamic shear-mediated platelet activation-Initial validation versus the standardized hemodynamic shearing device.Biomicrofluidics · 2018Article
- Thrombosis-on-a-chip: Prospective impact of microphysiological models of vascular thrombosis.Current opinion in biomedical engineering · 2018Article
- Is There a Relationship between Pressure Gradients through Contemporary Oxygenators and Immune Cell Proliferation during Cardiopulmonary Bypass? A Pilot Study.The journal of extra-corporeal technology · 2017Article
- High Frequency Components of Hemodynamic Shear Stress Profiles are a Major Determinant of Shear-Mediated Platelet Activation in Therapeutic Blood Recirculating Devices.Scientific reports · 2017Article
- Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques.Scientific reports · 2016Article
- Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner.Artificial organs · 2016Article
- Aspirin has limited ability to modulate shear-mediated platelet activation associated with elevated shear stress of ventricular assist devices.Thrombosis research · 2016Article
- Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation.Biomedical microdevices · 2015Article
- The role of hemostasis in infective endocarditis.Current infectious disease reports · 2014Article
- Platelet GpIba binding to von Willebrand Factor under fluid shear:contributions of the D′D3-domain, A1-domain flanking peptide and O-linked glycans.Journal of the American Heart Association · 2014Article
- A novel mathematical model of activation and sensitization of platelets subjected to dynamic stress histories.Biomechanics and modeling in mechanobiology · 2013Article
- Device thrombogenicity emulation: a novel methodology for optimizing the thromboresistance of cardiovascular devices.Journal of biomechanics · 2013Article
- Polymeric trileaflet prosthetic heart valves: evolution and path to clinical reality.Expert review of medical devices · 2012Review
- Prosthetic heart valve obstruction: thrombolysis or surgical treatment?European heart journal. Acute cardiovascular care · 2012Article
- Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses.Circulation. Cardiovascular interventions · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Altered and highly dynamic shear stress conditions have been implicated in endothelial dysfunction leading to cardiovascular disease, and in thromboembolic complications in prosthetic cardiovascular devices. In addition to vascular damage, the pathological flow patterns characterizing cardiovascular pathologies and blood flow in prosthetic devices induce shear activation and damage to blood constituents. Investigation of the specific and accentuated effects of such flow-induced perturbations on individual cell-types in vitro is critical for the optimization of device design, whereby specific design modifications can be made to minimize such perturbations. Such effects are also critical in understanding the development of cardiovascular disease. This review addresses limitations to replicate such dynamic flow conditions in vitro and also introduces the idea of modified in vitro devices, one of which is developed in the authors' laboratory, with dynamic capabilities to investigate the aforementioned effects in greater detail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.