ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways.Scientific reports · 2016Article
- Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice.PLoS genetics · 2015Article
- Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells.PloS one · 2015Article
- High histone variant H3.3 content in mouse prospermatogonia suggests a role in epigenetic reformatting.Chromosoma · 2014Article
- Epigenetics and memigenetics.Cellular and molecular life sciences : CMLS · 2014Review
- The putative promoters of germ cell-specific genes and Nanog are hypomethylated in chicken sperm.The Journal of reproduction and development · 2014Article
- Toward a more precise and informative nomenclature describing fetal and neonatal male germ cells in rodents.Biology of reproduction · 2013Review
- De novo DNA methylation in the male germ line occurs by default but is excluded at sites of H3K4 methylation.Cell reports · 2013Article
- Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells.PLoS genetics · 2012Article
- Uncovering gene regulatory networks during mouse fetal germ cell development.Biology of reproduction · 2011Article
- Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.Nature genetics · 2011Article
- CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.PLoS genetics · 2010Article
- Testicular postgenomics: targeting the regulation of spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mammalian totipotent and pluripotent lineage exhibits genome-wide dynamics with respect to DNA methylation content. The first phase of global DNA demethylation and de novo remethylation occurs during preimplantation development and gastrulation, respectively, while the second phase occurs in primordial germ cells and primary oocytes/prospermatogonia, respectively. These dynamics are indicative of a comprehensive epigenetic resetting or reprogramming of the genome in preparation for major differentiation events. To gain further insight into the mechanisms driving DNA methylation dynamics and other types of epigenetic modification, we performed an RNA expression microarray analysis of fetal prospermatogonia at the stage when they are undergoing rapid de novo DNA remethylation. We have identified a number of highly or specifically expressed genes that could be important for determining epigenetic change in prospermatogonia. These data provide a useful resource in the discovery of molecular pathways involved in epigenetic reprogramming in the mammalian germ line.
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