ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2008
Serum paraoxonase undergoes inhibition and proteolysis during experimental acute pancreatitis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Acute phase proteins and total antioxidant capacity in free-roaming cats infected by pathogenic leptospires.BMC veterinary research · 2023Article
- Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review).Experimental and therapeutic medicine · 2022Review
- HDL Proteome and Alzheimer's Disease: Evidence of a Link.Antioxidants (Basel, Switzerland) · 2020Review
- The Role ofGlobal medical genetics · 2020Review
- Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial.The Libyan journal of medicine · 2019Article
- Decreases in Paraoxonase-1 Activities Promote a Pro-inflammatory Effect of Lipids Peroxidation Products in Non-smoking and Smoking Patients with Acute Pancreatitis.International journal of medical sciences · 2018Article
- Serum biomarkers of oxidative stress in cats with feline infectious peritonitis.Research in veterinary science · 2015Article
- Serum paraoxonase 1 (PON1) measurement: an update.BMC veterinary research · 2014Review
- Low paraoxonase 1 activity predicts mortality in surgical patients with sepsis.Disease markers · 2014Observational
- Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats.Toxicology letters · 2012Article
- Regulation of hepatic paraoxonase-1 expression.Journal of lipids · 2012Article
- Pharmacologically directed cell disposal: labeling damaged cells for phagocytosis as a strategy against acute pancreatitis.Molecular interventions · 2010Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has a primary role in the pathogenesis of severe acute pancreatitis. Then, the antioxidant capacity is a critical factor in the progression of this disease. Serum paraoxonase-1 (PON1) is an esterase associated with high-density lipoprotein, which clinical interest resides in its ability to prevent or limit the lipid oxidation. The aim of this study was to investigate changes in PON1 activity in the early stages of acute pancreatitis and to find out if its alteration is related with the severity of the disease. To this purpose, we used an experimental model of taurocholate-induced mild and severe acute pancreatitis. Our results showed that serum activity and PON1 concentration decreased 18 h after the induction of a severe acute pancreatitis. In vitro analysis revealed that incubation with oxidized lipids obtained from pancreatitis samples results in the inactivation of the enzyme in a concentration-dependent manner. In addition to oxidative inactivation, we observed by Western blot, an immunoreactive band suggestive of proteolytic degradation of the enzyme, altogether indicating that during severe acute pancreatitis, there is a significant decrease in serum PON1 activity. This decrease is related with inactivation of the enzyme by oxidized lipids, probably followed by proteolytic degradation of the enzyme.
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