ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2008
Lemierre's syndrome and other disseminated Fusobacterium necrophorum infections in Denmark: a prospective epidemiological and clinical survey.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
132 citing papers in PubMed, 2 syntheses or guidelines pooled it, 274 citations in OpenAlex.
- Acute sore throat andBMJ open · 2021Pooled it
- A systematic review of Fusobacterium necrophorum-positive acute tonsillitis: prevalence, methods of detection, patient characteristics, and the usefulness of the Centor score.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Pooled it
- Rare bacterial infections and metagenomics: current diagnostic and therapeutic challenges-a literature review.Infection · 2026Review
- Lemierre Syndrome After Influenza A Virus Infection.Cureus · 2026Article
- Visceral variant of Lemierre's syndrome presenting with liver abscess, hepatic vein thrombophlebitis, and septic pulmonary emboli.Oxford medical case reports · 2026Article
- Article
- Incomplete Lemierre's syndrome: a case report.Journal of medical case reports · 2026Article
- A Closer Examination of Sore Throats and Their Hidden Dangers: A Case Report of Lemierre's Syndrome.Cureus · 2026Article
- Biphasic Clinical Course Revealing Lemierre's Syndrome Following Acute Pharyngotonsillitis: A Case Report.Cureus · 2026Article
- Lemierre Syndrome Presenting With Septic Pulmonary Emboli: A Case Report and Diagnostic Challenges.Cureus · 2026Article
- Lemierre syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Central nervous system complications: atypical manifestation of Lemierre syndrome.BMC neurology · 2026Article
- Severe Necrotizing Community-Acquired Pneumonia and Bilateral Empyema in an Immunocompetent Patient due toCase reports in pulmonology · 2026Article
- Lemierre's Syndrome With External Jugular Vein Thrombosis Following Submandibular Sialadenitis: A Life-Threatening Complication.Case reports in otolaryngology · 2026Article
- Expanding the clinical spectrum of Lemierre syndrome and Lemierre-like septic internal jugular vein thrombophlebitis: a four-case series.Frontiers in medicine · 2026Article
- Anticoagulation Treatment in Patients with Septic Thrombophlebitis of the Internal Jugular Vein.The western journal of emergency medicine · 2025Article
- Microbiological diversity among patients with Lemierre syndrome and clinical implications: an individual patient-level analysis.Infection · 2025Article
- The "Forgotten Disease" in a Healthy Young Adult: A Case Report of Lemierre's Syndrome.Cureus · 2025Article
- Unmasking Rarity: An Atypical Presentation of Lemierre's Syndrome.Clinical case reports · 2025Article
- Culture-Negative Lemierre's Syndrome: A Case Report of Septic Thrombophlebitis With Multi-organ Involvement.Cureus · 2025Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a 3-year prospective study, all cases of disseminated Fusobacterium necrophorum infections found in Denmark from 1998 to 2001 were analysed, with the aim of describing the epidemiology and clinical features of the variants of Lemierre's syndrome and disseminated non-head-and-neck-associated F. necrophorum infections. Fifty-eight cases of Lemierre's syndrome were reported in previously healthy persons, with an incidence of 14.4 cases per million per year in youngsters aged 15-24 years old. There was no increase during the study period. Lemierre's syndrome originating from an oropharyngeal infection was seen in 37 youngsters. An otogenic variant of Lemierre's syndrome was seen in 5 children with dissemination to nearby regions, and other variants of Lemierre's syndrome, e.g. from the sinuses and teeth, were seen in 16 adults. Patients often had metastatic infections already on admission and needed prolonged hospitalisation. The overall mortality of Lemierre's syndrome was 9%. Forty-two elderly patients had disseminated F. necrophorum infections originating from foci in lower parts of the body. They frequently had predisposing diseases, e.g. abdominal or urogenital cancers, which contributed to the high mortality of 26%. This study shows that the incidence of Lemierre's syndrome is higher than that previously found and has a characteristic age distribution. Early suspicion of the diagnosis, several weeks of antibiotic therapy, often combined with surgical drainage, is mandatory to lower the mortality. In disseminated non-head-and-neck-associated F. necrophorum infections, underlying cancers must be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.