ArticleImmunogenetics2008
Mannose-binding lectin haplotypes influence Brucella abortus infection in the water buffalo (Bubalus bubalis).
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
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- Complement component 3 haplotypes influence serum complement activity and milk production traits in Chinese Holstein cattle.PloS one · 2022Article
- Whole-genome sequencing of the endangered bovine species Gayal (Bos frontalis) provides new insights into its genetic features.Scientific reports · 2016Article
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- Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein.Molecular biology reports · 2014Article
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- SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene.Molecular biology reports · 2013Article
- Mannose-binding lectin 1 haplotypes influence serum MBL-A concentration, complement activity, and milk production traits in Chinese Holstein cattle.Immunogenetics · 2011Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A case-control study established that the haplotype pair HYA/HYA at the MBL (mannose binding lectin) locus of water buffalo is associated with resistance to Brucella abortus infection (P < 10(-7)) and the haplotype pairs LYD/LYD with susceptibility to the same pathogen (P < 10(-7)). The subjects included in the present study were tested twice-at a 1-month interval-for the presence of anti-B. abortus antibodies in the serum by agglutination, complement fixation and flow cytometry. Cases (335 subjects) included animals consistently positive to all these tests; controls (335 subjects) comprised animals exposed yet negative by the same tests. The serum from genetically resistant subjects displayed in vitro significantly higher antibacterial activity compared to the serum from genetically susceptible subjects, lending biological significance to the results from the association study. Inhibition of the antibacterial activity following heat treatment of the serum, addition of specific MBL inhibitors (EDTA, mannose, N-acetyl-D: -glucosamine) or anti-human MBL antiserum provide convincing evidence that the antibacterial activity present in the serum results from the interaction between MBL and B. abortus. A replication study (comprising 100 cases and 100 controls) confirmed the results from the original study.
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