ArticleEuropean biophysics journal : EBJ2008
Water structure around dipeptides in aqueous solutions.
Article in European biophysics journal : EBJ, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 34 citations in OpenAlex.
- Visualising reaction complexes in amine-based unloaded and CONature communications · 2026Article
- Walking on water: revisiting the role of water in articular cartilage biomechanics in relation to tissue engineering and regenerative medicine.Journal of the Royal Society, Interface · 2022Review
- Water-peptide site-specific interactions: a structural study on the hydration of glutathione.Biophysical journal · 2014Article
- Dipeptide Aggregation in Aqueous Solution from Fixed Point-Charge Force Fields.Journal of chemical theory and computation · 2014Article
- Alteration of water structure by peptide clusters revealed by neutron scattering in the small-angle region (below 1 Å(-1)).Biophysical journal · 2012Article
- A bulk water-dependent desolvation energy model for analyzing the effects of secondary solutes on biological equilibria.Biochemistry · 2011Article
- Hydration water and bulk water in proteins have distinct properties in radial distributions calculated from 105 atomic resolution crystal structures.The journal of physical chemistry. B · 2008Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bulk water structure around small peptide fragments--glycyl-L-alanine, glycyl-L-proline and L:-alanyl-L-proline-has been determined by a combination of neutron diffraction with isotopic substitution and empirical potential structural refinement techniques. The addition of each of the dipeptides to water gives rise to decreased water-water coordination in the surrounding water solvent. Additionally, both the Ow-Ow radial distribution functions and the water-water spatial density functions in all of the solutions indicate an electrostrictive effect in the second water coordination shell of the bulk water network. This effect is not observed in similar experiments on the amino acid L: -proline alone in solution, which is one component of two of the peptides measured here.
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