Evidence map›Paper›PMID 18329534›Full record

ReviewRheumatic diseases clinics of North America2008

Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.

Nicholas A Flavahan

Open access · greenAbstract readReview
In one paragraph

Review in Rheumatic diseases clinics of North America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Local thermal control of the human cutaneous circulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2010
    Review
  10. Aging and the control of human skin blood flow.Frontiers in bioscience (Landmark edition) · 2010
    Article
  11. Vascular disease in scleroderma.Clinical reviews in allergy & immunology · 2009
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nicholas A FlavahanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Johns Hopkins University · US

Funding

alpha2C Adrenergic Receptors &Cutaneous CirculationR01HL080119 · NHLBI · OHIO STATE UNIVERSITY · PI FLAVAHAN, NICHOLAS A · 2005 to 2009
$1.7M
Mechanisms of Vascular Dysfunction in Vibration InjuryR01OH008531 · OH · OHIO STATE UNIVERSITY · PI FLAVAHAN, NICHOLAS A · 2005 to 2009
$1.0M
NHLBI NIH HHS HL080119NHLBI NIH HHS R01 HL080119NIOSH CDC HHS OH008531NIOSH CDC HHS R01 OH008531
6 · The paper itself

Abstract

Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.

Indexed as

Cold TemperatureHumansMuscle, Smooth, VascularRaynaud DiseaseReactive Oxygen SpeciesReceptors, Adrenergicrho-Associated KinasesScleroderma, SystemicSignal TransductionSkin TemperatureReactive Oxygen SpeciesReceptors, Adrenergicrho-Associated Kinases

Identifiers

PMID18329534
PMCPMC2336896
OpenAlexW2138686855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.