ReviewAgeing research reviews2008
Caloric restriction: impact upon pituitary function and reproduction.
Review in Ageing research reviews, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- A literature review of biomarkers used for diagnosis of relative energy deficiency in sport.Frontiers in sports and active living · 2024Pooled it
- A Systematic Literature Review and Meta-Regression Analysis on Early-Life Energy Restriction and Cancer Risk in Humans.PloS one · 2016Pooled it
- Effects of Short-Term Low Energy Availability on Metabolism and Performance-Related Parameters in Physically Active Adults.Nutrients · 2025Trial
- Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity.The Journal of clinical endocrinology and metabolism · 2024Trial
- Rethinking Energy Availability from Conceptual Models to Applied Practice: A Narrative Review.Nutrients · 2026Review
- Linking Ghrelin Elevation to Reproductive Dysfunction: Insights from Feed-Restricted Male Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Long-term dietary restriction changes lipid homeostasis and consequently impairs testosterone production in agedFrontiers in nutrition · 2025Article
- Experimental analysis of acupuncture's effects on hyperandrogenemia and related symptoms in PCOS patients.Frontiers in medicine · 2025Review
- Prevalence of low energy availability and associations with seasonal changes in salivary hormones and IgA in elite male Gaelic footballers.European journal of nutrition · 2023Article
- Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models.Annual review of nutrition · 2022Review
- The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease.International journal of molecular sciences · 2022Review
- Male Bowhead Whale Reproductive Histories Inferred from Baleen Testosterone and Stable Isotopes.Integrative organismal biology (Oxford, England) · 2022Article
- The Female Athlete Triad/Relative Energy Deficiency in Sports (RED-S).Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021Review
- Caloric restriction in female reproduction: is it beneficial or detrimental?Reproductive biology and endocrinology : RB&E · 2021Review
- Exploratory Analysis in the Differences in Blood Serum and Seminal Plasma of Adipose-Tissue Related Peptides in Obese and Non-Obese Men and Their Correlations With Semen Parameters.Frontiers in endocrinology · 2021Article
- Long-Term Effect of Environmental Enrichment on Reproductive Performance of Swiss Webster Mice and Their Female Offspring.Animals : an open access journal from MDPI · 2020Article
- Effects of body condition score and estrus phase on blood metabolites and steroid hormones in Saanen goats in the tropics.Veterinary world · 2020Article
- Physiological response of crossbred sheep under nutritional scarcity.Tropical animal health and production · 2019Article
- Gonadal hormones influence core body temperature during calorie restriction.Temperature (Austin, Tex.) · 2019Article
- Aging and Alzheimer's disease: Comparison and associations from molecular to system level.Aging cell · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Reduced energy intake, or caloric restriction (CR), is known to extend life span and to retard age-related health decline in a number of different species, including worms, flies, fish, mice and rats. CR has been shown to reduce oxidative stress, improve insulin sensitivity, and alter neuroendocrine responses and central nervous system (CNS) function in animals. CR has particularly profound and complex actions upon reproductive health. At the reductionist level the most crucial physiological function of any organism is its capacity to reproduce. For a successful species to thrive, the balance between available energy (food) and the energy expenditure required for reproduction must be tightly linked. An ability to coordinate energy balance and fecundity involves complex interactions of hormones from both the periphery and the CNS and primarily centers upon the master endocrine gland, the anterior pituitary. In this review article we review the effects of CR on pituitary gonadotrope function and on the male and female reproductive axes. A better understanding of how dietary energy intake affects reproductive axis function and endocrine pulsatility could provide novel strategies for the prevention and management of reproductive dysfunction and its associated comorbidities.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.