ArticleEnvironmental research2008
Effects of diesel exhaust inhalation on heart rate variability in human volunteers.
Article in Environmental research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Cardiovascular effects of sub-daily levels of ambient fine particles: a systematic review.Environmental health : a global access science source · 2010Pooled it
- Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.Particle and fibre toxicology · 2014Trial
- Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists.Environmental health perspectives · 2011Trial
- ECG parameters and exposure to carbon ultrafine particles in young healthy subjects.Inhalation toxicology · 2009Trial
- The impacts of short-term exposure to noise and traffic-related air pollution on heart rate variability in young healthy adults.Journal of exposure science & environmental epidemiologyTrial
- Modelling the time-resolved modulations of cardiac activity in rats: A study on pharmacological autonomic stimulation.The Journal of physiology · 2026Article
- The association between ozone exposure and blood pressure in a general Chinese middle-aged and older population: a large-scale repeated-measurement study.BMC medicine · 2024Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Air pollution exposure and cardiometabolic risk.The lancet. Diabetes & endocrinology · 2024Review
- Altered Heart Rate Variability During Mobile Game Playing and Watching Self-Mobile Gaming in Individuals with Problematic Mobile Game Use: Implications for Cardiac Health.Psychology research and behavior management · 2024Article
- Controlled human exposure to diesel exhaust: a method for understanding health effects of traffic-related air pollution.Particle and fibre toxicology · 2022Review
- Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions.Particle and fibre toxicology · 2022Review
- Irritant Inhalation Evokes P Wave Morphological Changes in Spontaneously Hypertensive Rats via Reflex Modulation of the Autonomic Nervous System.Frontiers in physiology · 2021Article
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- Heart rate variability and cardiac repolarization after exposure to zinc oxide nanoparticles in healthy adults.Journal of occupational medicine and toxicology (London, England) · 2020Article
- Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat.The Journal of physiology · 2019Article
- Health effects of exposure to diesel exhaust in diesel-powered trains.Particle and fibre toxicology · 2019Article
- The pulmonary and autonomic effects of high-intensity and low-intensity exercise in diesel exhaust.Environmental health : a global access science source · 2018Article
- Altered Heart Rate Variability During Gameplay in Internet Gaming Disorder: The Impact of Situations During the Game.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesParticulate matter (PM) air pollution is associated with alterations in cardiac conductance and sudden cardiac death in epidemiological studies. Traffic-related air pollutants, including diesel exhaust (DE) may be at least partly responsible for these effects. In this experimental study we assessed whether short-term exposure to DE would result in alterations in heart rate variability (HRV), a non-invasive measure of autonomic control of the heart.
methodsIn a double-blind, crossover, controlled-exposure study, 16 adult volunteers were exposed (at rest) in randomized order to filtered air (FA) and two levels of diluted DE (100 or 200 microg/m(3) of fine particulate matter) in 2-h sessions. Before, and at four time points after each exposure we assessed HRV. HRV parameters assessed included both time domain statistics (standard deviation of N-N intervals (SDNN), and the square root of the mean of the sum of squared differences between successive N-N intervals (RMSSD)) and frequency domain statistics (high-frequency (HF) power, low-frequency (LF) power, and the LF/HF ratio).
resultsWe observed an effect at 3-h after initiation of DE inhalation on the frequency domain statistics of HRV. DE at 200 microg/m(3) elicited an increase in HF power compared to FA (Delta=0.33; 95% CI: 0.01-0.7) and a decrease in LF/HF ratio (Delta=-0.74; 95% CI: -1.2 to -0.2). The effect of DE on HF power was not consistent among study participants. There was no DE effect on time domain statistics and no significant DE effect on HRV in later time points.
conclusionsWe did not observe a consistent DE effect on the autonomic control of the heart in a controlled-exposure experiment in young participants. Efforts are warranted to understand discrepancies between epidemiological and experimental studies of air pollution's impact on HRV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.