SynthesisWorld journal of surgery2008
Surgical treatment of Graves' disease: evidence-based approach.
Synthesis in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01408368 (Five-year Follow up of a Randomized Clinical Trial of Bilateral Subtotal Thyroidectomy Versus Total Thyroidectomy for Graves' Disease.), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Five-year Follow up of a Randomized Clinical Trial of Bilateral Subtotal Thyroidectomy Versus Total Thyroidectomy for Graves' Disease.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease.Langenbeck's archives of surgery · 2011Guideline
- Extent of Surgery in the Surgical Treatment of Graves' Disease: Subtotal vs. Total Thyroidectomy and Comparison of the Long-term Results.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Long-Term Outcome of Graves' Disease: A Gender Perspective.Women's health reports (New Rochelle, N.Y.) · 2023Article
- Outcomes After Urgent Thyroidectomy Following Rapid Control of Thyrotoxicosis in Graves' Disease are Similar to Those After Elective Surgery in Well-Controlled Disease.World journal of surgery · 2019Article
- Article
- Does Surgery Without Lugol's Solution Pretreatment for Graves' Disease Increase Surgical Morbidity?World journal of surgery · 2018Article
- Impact of potassium iodide on thyroidectomy for Graves' disease: Implications for safety and operative difficulty.Surgery · 2018Article
- Total thyroidectomy as primary surgical management for thyroid disease: surgical therapy experience from 5559 thyroidectomies in a less-developed region.World journal of surgical oncology · 2016Observational
- Total thyroidectomy as a method of choice in the treatment of Graves' disease - analysis of 1432 patients.BMC surgery · 2015Article
- Clinical and socioeconomic factors influence treatment decisions in Graves' disease.Annals of surgical oncology · 2015Article
- Endoscopic thyroidectomy via areola approach: summary of 1,250 cases in a single institution.Surgical endoscopy · 2015Article
- Changes in the choice of thyroidectomy for benign thyroid disease.Surgery today · 2013Article
- Changing trends in surgery for Graves' disease: a cohort comparison of those having surgery intended to preserve thyroid function with those having ablative surgery.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2013Article
- Pediatric thyroid disease: when is surgery necessary, and who should be operating on our children?Journal of clinical research in pediatric endocrinology · 2013Review
- Management of Grave's disease is improved by total thyroidectomy.World journal of surgery · 2012Article
- Disparity in the management of Graves' disease observed at an urban county hospital: a decade-long experience.American journal of surgery · 2012Article
- Greater Efficacy of Total Thyroidectomy versus Radioiodine Therapy on Hyperthyroidism and Thyroid-Stimulating Immunoglobulin Levels in Patients with Graves' Disease Previously Treated with Antithyroid Drugs.European thyroid journal · 2012Article
- Alternating from subtotal thyroid resection to total thyroidectomy in the treatment of Graves' disease prevents recurrences but increases the frequency of permanent hypoparathyroidism.Langenbeck's archives of surgery · 2012Article
- Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism.TheScientificWorldJournal · 2012Article
- Graves' ophthalmopathy as an indication increased the risk of hypoparathyroidism after bilateral thyroidectomy.World journal of surgery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal treatment of Graves disease (GD) is still controversial. Surgery is one treatment option along with radioactive iodine (RAI) and antithyroid medication. In this evidence-based review, we examine four issues: (1) Is surgery better than RAI or long-term antithyroid medication? (2) What is the recommended surgical approach? (3) How does the presence of Graves' ophthalmopathy (GO) influence the role of surgery? (4) What is the role of surgery in children with GD?
methodsWe conducted a systematic review of the literature using evidence-based criteria regarding these four issues.
results(1) There are no recommendations reaching any grade of evidence for which treatment to choose for adults with GD. (2) Total thyroidectomy has complication rates equal to those seen with lesser resections but it has higher cure rates and negligible recurrence rates (Level I-IV data leading to a grade A recommendation). (3) Data support surgery when severe GO is present, but RAI combined with glucocorticoids may be equally safe (Level II-IV data, grade B recommendation). The extent of thyroid resection does not influence the outcome of GO (Level II data, grade B recommendation). (4) Based on the available data, definitive treatment can be advocated for children (Level IV data, grade C recommendation) using either RAI or surgery. No recommendation can be given as to whether RAI or surgery is preferred owing to the lack of studies addressing this issue. Increased cancer risk with RAI in children below the age of 5 years supports surgery in this setting (Level I data, grade A recommendation).
conclusionIf surgery is considered for definitive management, evidence-based criteria support total thyroidectomy as the surgical technique of choice for GD. Available evidence also supports surgery in the presence of severe endocrine GO. Children with GD should be treated with an ablative strategy. Whether this is achieved by total thyroidectomy or RAI may still be debatable. Data on long-term cancer risk are missing or conflicting; and until RAI has proven harmless in children, we continue to recommend surgery in this group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.