ArticleInvestigative ophthalmology & visual science2008
Resisting the effects of aging: a function for the fiber cell beaded filament.
Article in Investigative ophthalmology & visual science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.Progress in retinal and eye research · 2026Review
- Nonmuscle myosin IIA (NMIIA) regulates anisotropic cell tension to maintain the hexagonal packing of mouse lens meridional row cells.Molecular biology of the cell · 2025Article
- Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Effects of truncations in the N- and C-terminal domains of filensin on filament formation with phakinin in cell-free conditions and cultured cells.FEBS open bio · 2023Article
- Nonmuscle Myosin IIA Regulates the Precise Alignment of Hexagonal Eye Lens Epithelial Cells During Fiber Cell Formation and Differentiation.Investigative ophthalmology & visual science · 2023Article
- Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens.Experimental eye research · 2021Article
- Localization of the lens intermediate filament switch by imaging mass spectrometry.Experimental eye research · 2020Article
- CP49 and filensin intermediate filaments are essential for formation of cold cataract.Molecular vision · 2020Article
- Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers.Experimental eye research · 2019Article
- Spatially Directed Proteomics of the Human Lens Outer Cortex Reveals an Intermediate Filament Switch Associated With the Remodeling Zone.Investigative ophthalmology & visual science · 2016Article
- Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells.Investigative ophthalmology & visual science · 2016Article
- Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.Bioarchitecture · 2016Article
- Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium.Molecular vision · 2016Article
- Role of Aquaporin 0 in lens biomechanics.Biochemical and biophysical research communications · 2015Article
- Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells.American journal of physiology. Cell physiology · 2015Article
- Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice.Experimental eye research · 2014Article
- Myo/Nog cells: targets for preventing the accumulation of skeletal muscle-like cells in the human lens.PloS one · 2014Article
- Mass spectrometry of membrane proteins: a focus on aquaporins.Biochemistry · 2013Review
- A role for γS-crystallin in the organization of actin and fiber cell maturation in the mouse lens.The FEBS journal · 2012Article
- Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThe beaded filament is a cytoskeletal structure that has been found only in the lens fiber cell. It includes phakosin and filensin, two divergent members of the intermediate filament family of proteins that are also unique to the fiber cell. The authors sought to determine what function the beaded filament fulfills in the lens.
methodsLight microscopy and electron microscopy were used to characterize structural changes that occurred in previously generated phakosin and filensin knockout mice. Immunocytochemistry and electron microscopy were used to define the distribution of phakosin, filensin, and beaded filaments.
resultsIn phakosin and filensin knockout mice, initial lens development and the early phases of fiber cell differentiation proceed in a manner largely indistinguishable from that of wild type. Fiber cells elongate, undergo organelle elimination, and, in the organelle-free zone, develop the unique paddlelike extensions that characterize cells in this region. Subsequent to those stages, however, fiber cells undergo loss of the differentiated fiber cell phenotype and loss of the long-range stacking that characterizes fiber cells and that has been considered essential for clarity.
conclusionsThe beaded filament is not required for the generation of the differentiated fiber cell phenotype but is required to maintain that differentiated state and the long range order that characterizes the lens at the tissue level.
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